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Prognostic Performance of C-Reactive Protein for Tuberculosis Outcome: Protocol for a Systematic Review and
Jessica Edelyne1,2,3, Muhammad Prasetio Wardoyo3, Luthfiyah Zanida Putri3
1Master in Biomedical Sciences, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Senolowo, Jl. Farmako, Sekip Utara, Kec Depok, Kabupaten Sleman, Daerah Istimewa Yogyakarta, 55281, Indonesia, 62 274-560-300.
JMIR Research Protocols
|June 16, 2026
Summary
C-reactive protein (CRP) shows potential as a prognostic biomarker for tuberculosis (TB) mortality. This systematic review synthesizes evidence on CRP
Area of Science:
- Infectious Diseases
- Biomarkers
- Public Health
Background:
- Tuberculosis (TB) presents a significant global health burden with high mortality.
- Accurate prognostication of TB outcomes is challenging due to the lack of routine host-derived biomarkers.
- C-reactive protein (CRP), an acute-phase reactant, is a potential prognostic biomarker for TB mortality.
Purpose of the Study:
- To systematically evaluate the prognostic value of baseline C-reactive protein (CRP) in predicting mortality among adult TB patients.
- To examine how the association between CRP and TB mortality varies across clinical subgroups and study characteristics.
Main Methods:
- Systematic review and meta-analysis protocol adhering to PRISMA-P guidelines.
- Inclusion of English-language cohort, observational, case-control studies, and RCT control arms involving adults with confirmed TB.
- Assessment of baseline CRP and quantitative mortality data; risk of bias evaluated using QUIPS; certainty of evidence using GRADE.
Main Results:
- Protocol prospectively registered in PROSPERO (CRD420251101984) in July 2025.
- Literature search conducted from database inception to June 30, 2025.
- Data extraction, methodological appraisal, and evidence synthesis completed for manuscript preparation.
Conclusions:
- This protocol outlines a transparent approach to evaluating CRP as a prognostic biomarker for TB mortality.
- The completed systematic review will clarify CRP's role in TB care and identify research gaps.
- Findings are expected to guide future prognostic research in tuberculosis.
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