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Updated: Jun 18, 2026

A Practical Guide to Phylogenetics for Nonexperts
Published on: February 5, 2014
PhyloNaP: a user-friendly database of phylogeny for natural product-producing enzymes
Aleksandra Korenskaia1, Martina Adamek1,2, Judit Szenei3
1Translational Genome Mining for Natural Products, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), Interfaculty Institute for Biomedical Informatics (IBMI), University of Tübingen, Tübingen, 72076, Germany.
Summary:
Phylogenetic analysis is widely used to predict enzyme function, yet building annotated and reusable trees is labor-intensive and requires extensive knowledge about the specific enzymes. Existing resources rarely cover biosynthetic enzymes and lack the context needed for meaningful analysis. We present PhyloNaP, the first large-scale resource dedicated to phylogenies of biosynthetic enzymes. PhyloNaP provides ∼51 000 annotated and interactive trees enriched with chemical, functional, and taxonomic information. Users can classify their own sequences via phylogenetic placement, enabling functional inference in an evolutionary context. A contribution portal allows the community to submit curated trees. By combining scale, breadth of annotation, and interactive functionality, PhyloNaP fills a major gap in bioinformatics resources for enzyme discovery and annotation, with immediate applications to secondary metabolism and beyond.
Availability And Implementation:
Freely available on the web at https://phylonap.cs.uni-tuebingen.de.
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