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Standards of Care II01:19

Standards of Care II

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Standards of Care I01:22

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Guidelines for Writing Outcome01:11

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Healthcare Associated Infections II: Preventive Measures

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Developing a Core Outcome Measurement Set for Adult ICU Patients, the CoreMS-ICU-A Protocol.

Maj-Brit Nørregaard Kjær1,2, Camilla Rahbek Lysholm Bruun1, Camilla Bekker Mortensen3

  • 1Department of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.

Acta Anaesthesiologica Scandinavica
|June 16, 2026
PubMed
Summary

This study develops a Core Outcome Measurement Set (COMS) for critically ill adult ICU patients. This standardized approach ensures consistent outcome measurement in clinical research for better patient care.

Keywords:
clinical researchcore outcome measurement setpatient‐centred outcomesstakeholder involvement

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Area of Science:

  • Critical Care Medicine
  • Clinical Research Methodology
  • Health Outcomes Research

Background:

  • Core Outcome Measurement Sets (COMS) improve consistency in clinical research outcomes.
  • Existing COMS are subgroup-specific for intensive care unit (ICU) patients.
  • A standardized approach is needed for outcome measurement in acutely admitted adult ICU patients.

Purpose of the Study:

  • To develop a Core Outcome Measurement Set (COMS) for adults acutely admitted to the ICU.
  • To standardize outcome measurement and operationalization for ICU clinical research.
  • To enhance the consistency and comparability of outcome reporting in ICU trials.

Main Methods:

  • Protocol development for the CoreMS-ICU.
  • Following the Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN) guideline.
  • Five steps: conceptualization, systematic search, quality assessment, consensus selection, and operationalization guidance.
  • Involving patients, families, healthcare professionals, and researchers.

Main Results:

  • The CoreMS-ICU will include six core outcomes: survival, free of life support, free of delirium, out of hospital, health-related quality of life, and cognitive function.
  • Systematic searches and quality assessments of measurement instruments will be conducted.
  • Consensus-based selection will identify the most valid, reliable, and feasible instruments.

Conclusions:

  • The developed COMS will facilitate consistent outcome use in ICU trials.
  • This standardization aims to improve the translation of research findings into clinical practice.
  • Enhancing research quality and patient outcomes in critical care.