Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Determining the age of single cells using scMLEAge.

bioRxiv : the preprint server for biology·2026
Same author

Novel Taxol-Derivative, STO-1, Induces Selective Anti-Tumor Immunity and Sustained Remission of Glioblastoma Without Triggering Autoimmune Reactions.

Cells·2025
Same author

Dopamine signaling drives skin invasion by human-infective nematodes.

Nature communications·2025
Same author

Dynamics of Th1/Th17 responses and antimicrobial pathways in leprosy skin lesions.

The Journal of clinical investigation·2025
Same author

Insights into early acne pathogenesis: Exploring intercellular dynamics and key dysregulated genes.

Cell signaling·2025
Same author

Immune Activation and Glycolytic Responses to Cutibacterium acnes Cell Wall Polysaccharides.

The Journal of investigative dermatology·2025

Related Experiment Video

Updated: Jun 18, 2026

Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by Microbial and Chemical Stimuli
14:05

Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by Microbial and Chemical Stimuli

Published on: November 4, 2022

Cutibacterium acnes induce T cell extracellular traps with distinct proteome programs.

Thao Tam To1, Min Deng1, Priscila R Andrade1

  • 1Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA 90095, USA.

The Journal of Investigative Dermatology
|June 16, 2026
PubMed
Summary

Cutibacterium acnes strains differentially affect immune cell extracellular traps (ETs). Healthy skin strains promote antimicrobial functions, while acne strains induce inflammation and tissue remodeling.

Keywords:
Cutibacterium acnesExtracellular trapsT cell extracellular trapsacne vulgarisproteomics

More Related Videos

Visualizing Macrophage Extracellular Traps Using Confocal Microscopy
09:14

Visualizing Macrophage Extracellular Traps Using Confocal Microscopy

Published on: October 19, 2017

Neutrophil Extracellular Traps: How to Generate and Visualize Them
14:17

Neutrophil Extracellular Traps: How to Generate and Visualize Them

Published on: February 24, 2010

Related Experiment Videos

Last Updated: Jun 18, 2026

Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by Microbial and Chemical Stimuli
14:05

Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by Microbial and Chemical Stimuli

Published on: November 4, 2022

Visualizing Macrophage Extracellular Traps Using Confocal Microscopy
09:14

Visualizing Macrophage Extracellular Traps Using Confocal Microscopy

Published on: October 19, 2017

Neutrophil Extracellular Traps: How to Generate and Visualize Them
14:17

Neutrophil Extracellular Traps: How to Generate and Visualize Them

Published on: February 24, 2010

Area of Science:

  • Immunology
  • Microbiology
  • Dermatology

Background:

  • Cutibacterium acnes (C. acnes) is a skin bacterium linked to acne.
  • Extracellular traps (ETs) are released by immune cells to trap pathogens.
  • Neutrophil (NETs) and Th17 cell (TETs) derived ETs play roles in immunity.

Purpose of the Study:

  • To investigate if C. acnes strains from acne-prone skin (CA) and healthy skin (CH) differentially induce ETs in human neutrophils and Th17 cells.
  • To define the proteomic and functional properties of strain- and cell type-specific ETs.

Main Methods:

  • Stimulation of human neutrophils and Th17 cells with C. acnes strains.
  • Proteomic analysis of induced ETs.
  • Functional assays to assess antimicrobial and inflammatory activities.
  • Gene ontology analysis.

Main Results:

  • Both CA and CH strains induced ET release from neutrophils and Th17 cells.
  • Neutrophil ETs (NETs) had similar proteomes regardless of C. acnes strain.
  • Th17 cell ETs (TETs) showed strain-specific proteomic specialization.
  • CH-induced TETs were rich in antimicrobial proteins and mediated bacterial killing.
  • CA-induced TETs were enriched in inflammatory and matrix remodeling proteins.

Conclusions:

  • C. acnes strains differentially regulate ET composition and function in a cell type-specific manner.
  • Healthy skin-associated C. acnes (CH) induced TETs may support skin immune homeostasis.
  • Acne-associated C. acnes (CA) induced TETs may contribute to acne inflammation and tissue damage.