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Related Experiment Video

Updated: Jun 18, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Programmable stimuli-driven DNA nanostructures for biomedical application.

Jianmin Hu1, Chenchen Gu1, Kang Zhu1

  • 1State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|June 16, 2026
PubMed
Summary

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This summary is machine-generated.

Intelligent DNA nanostructures sense and respond to stimuli for precise biomedical applications. This review covers their use in molecular imaging, drug delivery, and therapy, highlighting future prospects.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Molecular Biology

Background:

  • DNA nanostructures are intelligent nanomaterials with programmable design and biocompatibility.
  • These structures can sense and respond to specific stimuli, leading to applications in medicine.
  • Recent advancements focus on stimuli-responsive DNA nanostructures for precise biomedical functions.

Purpose of the Study:

  • To systematically review the biomedical applications of stimuli-responsive DNA nanostructures over the past five years.
  • To focus on applications in precise molecular imaging, targeted drug delivery, and tailored therapy.
  • To outline current challenges and future prospects for these advanced DNA nanostructure materials.

Main Methods:

  • Systematic literature review of studies published in the last five years.
Keywords:
DNA nanostructuresMolecular imagingStimuli-drivenTailored therapyTargeted drug delivery

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Last Updated: Jun 18, 2026

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Published on: September 27, 2019

Designing a Bio-responsive Robot from DNA Origami
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  • Analysis of research focusing on stimuli-responsive DNA nanostructures in biomedical fields.
  • Categorization of applications into molecular imaging, drug delivery, and therapy.

    • Main Results:

    • Stimuli-responsive DNA nanostructures enable spatiotemporally precise activation of functionalities.
    • Key applications include enhanced molecular imaging, targeted drug delivery, and personalized therapy.
    • These nanostructures offer advantages like programmability, biocompatibility, and ease of modification.

    Conclusions:

    • Stimuli-responsive DNA nanostructures are promising for personalized medicine.
    • Further development is needed to address current challenges and realize future prospects.
    • Continued research aims to advance DNA nanodevices for next-generation medical treatments.