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Updated: Jun 18, 2026

Quantifying Infra-slow Dynamics of Spectral Power and Heart Rate in Sleeping Mice
10:56

Quantifying Infra-slow Dynamics of Spectral Power and Heart Rate in Sleeping Mice

Published on: August 2, 2017

Rice-memolin modulates prefrontal neural oscillations during sleep

Takeshi Nagahiro1, Sena Iijima1, Kisa Watanabe1

  • 1Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113-0033, Japan.

Journal of Pharmacological Sciences
|June 16, 2026
PubMed

Insights

Rice-memolin significantly reduced theta, beta, and high gamma brainwave activity in mice during sleep. These findings suggest rice-memolin modulates neural oscillations, potentially impacting cognitive functions.

Area of Science:

  • Neuroscience
  • Sleep Research
  • Pharmacology

Background:

  • Neural oscillations are crucial for information processing during sleep.
  • The medial prefrontal cortex (mPFC) plays a key role in cognitive functions.
  • Understanding how compounds like rice-memolin affect brain activity during sleep is important for cognitive enhancement.

Purpose of the Study:

  • To investigate the effects of rice-memolin on neural oscillations in the mouse medial prefrontal cortex (mPFC) during sleep.
  • To determine if rice-memolin alters specific frequency bands of brain activity during REM and non-REM sleep.
  • To assess the impact of rice-memolin on cardiac and autonomic functions.

Main Methods:

  • Mice were treated with rice-memolin.
  • Electrophysiological recordings were performed to measure neural oscillations in the mPFC during sleep.
  • Spectral analysis was used to quantify power in different frequency bands (theta, beta, high gamma).
  • Cardiac and autonomic functions were monitored.

Main Results:

  • Rice-memolin significantly attenuated theta power in the mPFC during REM sleep.
  • The power of beta and high gamma oscillations was significantly attenuated in the mPFC during non-REM sleep.
  • No significant changes were observed in cardiac and autonomic functions.

Conclusions:

  • Rice-memolin modulates cortical network dynamics by altering specific oscillatory bands in the mPFC during sleep.
  • These modulations in neural oscillations may underlie the procognitive properties of rice-memolin.
  • Further research is needed to elucidate the precise mechanisms of action and implications for cognitive processing.
Keywords:
Medial prefrontal cortexMouseRice-memolin

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