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Lasers for Melasma.
Valéria Campos1, Célia Kalil2, Luciane Zagonel3
1Valéria Campos Clinic; Department of Dermatology, Medical College of Jundiaí, Brazil.
Dermatologic Clinics
|June 16, 2026
Summary
Melasma, a complex skin pigmentation disorder, presents treatment challenges. Combination therapies using lasers and other agents show better results, but cautious application is needed to avoid side effects.
Area of Science:
- Dermatology
- Aesthetic Medicine
Background:
- Melasma is a chronic, multifactorial pigmentary condition.
- Pathophysiology involves melanin overproduction, photoaging, and hormonal influences.
- Treatment is often challenging due to its complex nature.
Purpose of the Study:
- To review the efficacy of various laser and light-based treatments for melasma.
- To evaluate the role of combination therapies in melasma management.
- To highlight the importance of maintenance and potential risks associated with laser treatments.
Main Methods:
- Review of current literature on laser and light-based therapies for melasma.
- Analysis of treatment outcomes for various modalities including intense pulsed light, photobiomodulation, and different laser types (Nd:YAG, nanosecond, picosecond, fractional).
- Assessment of combination therapy approaches and maintenance strategies.
Main Results:
- Multiple laser and light-based devices show promise for melasma treatment.
- No single modality provides a definitive solution.
- Combination therapies, integrating lasers with topical or oral agents, yield superior outcomes.
- Maintenance therapy is essential for preventing recurrence.
Conclusions:
- Laser and light-based treatments offer therapeutic options for melasma.
- Combination therapies are more effective than monotherapies.
- Cautious application of laser treatments is advised due to risks like postinflammatory hyperpigmentation, particularly in darker skin types.
- Ongoing research and careful patient selection are crucial for optimizing melasma management.
