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Updated: Jun 18, 2026

Using a 1064-nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser for Periorbital Hyperpigmentation
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Lasers for Melasma.

Valéria Campos1, Célia Kalil2, Luciane Zagonel3

  • 1Valéria Campos Clinic; Department of Dermatology, Medical College of Jundiaí, Brazil.

Dermatologic Clinics
|June 16, 2026
PubMed
Summary

Melasma, a complex skin pigmentation disorder, presents treatment challenges. Combination therapies using lasers and other agents show better results, but cautious application is needed to avoid side effects.

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Area of Science:

  • Dermatology
  • Aesthetic Medicine

Background:

  • Melasma is a chronic, multifactorial pigmentary condition.
  • Pathophysiology involves melanin overproduction, photoaging, and hormonal influences.
  • Treatment is often challenging due to its complex nature.

Purpose of the Study:

  • To review the efficacy of various laser and light-based treatments for melasma.
  • To evaluate the role of combination therapies in melasma management.
  • To highlight the importance of maintenance and potential risks associated with laser treatments.

Main Methods:

  • Review of current literature on laser and light-based therapies for melasma.
  • Analysis of treatment outcomes for various modalities including intense pulsed light, photobiomodulation, and different laser types (Nd:YAG, nanosecond, picosecond, fractional).
Keywords:
Energy-based devicesHyperpigmentationLaserLight-based devicesMelasmaTreatment

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Last Updated: Jun 18, 2026

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  • Assessment of combination therapy approaches and maintenance strategies.

    • Main Results:

    • Multiple laser and light-based devices show promise for melasma treatment.
    • No single modality provides a definitive solution.
    • Combination therapies, integrating lasers with topical or oral agents, yield superior outcomes.
    • Maintenance therapy is essential for preventing recurrence.

    Conclusions:

    • Laser and light-based treatments offer therapeutic options for melasma.
    • Combination therapies are more effective than monotherapies.
    • Cautious application of laser treatments is advised due to risks like postinflammatory hyperpigmentation, particularly in darker skin types.
    • Ongoing research and careful patient selection are crucial for optimizing melasma management.