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Updated: Jun 18, 2026
02:09
Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
Published on: April 12, 2024
Phenotyping bronchopulmonary dysplasia using magnetic resonance imaging
Samal Munidasa1, Paul S Kingma2, Jason C Woods3
1Pulmonary Medicine, Cincinnati Children's Hospital, 3333 Burnet Ave, Cincinnati, OH 45229, USA.
Paediatric Respiratory Reviews
|June 16, 2026
Summary
Bronchopulmonary dysplasia (BPD) involves lung, airway, and vascular issues. Advanced MRI imaging helps assess these BPD phenotypes for better infant care.
Area of Science:
- Neonatal Medicine
- Pediatric Pulmonology
- Medical Imaging
Background:
- Bronchopulmonary dysplasia (BPD) is a chronic lung disease in premature infants, marked by impaired lung development and ongoing respiratory problems.
- BPD presents with three main phenotypes: parenchymal lung disease (affecting alveoli and gas exchange), airway disease (causing obstruction), and pulmonary vascular disease (leading to pulmonary hypertension).
- These phenotypes can occur independently or concurrently, complicating patient management.
Purpose of the Study:
- To highlight the role of advanced Magnetic Resonance Imaging (MRI) techniques in evaluating the distinct phenotypes of Bronchopulmonary dysplasia (BPD).
- To demonstrate how MRI can provide non-invasive assessments of lung structure, function, and vasculature in infants with BPD.
- To underscore the potential of imaging-based phenotyping for improved disease monitoring, risk stratification, and personalized treatment strategies in BPD.
Main Methods:
- Review of advanced MRI techniques applicable to BPD phenotyping.
- Description of MRI's capability to assess lung structure (alveolar growth, emphysema), airway dynamics (malacia, stenosis), and pulmonary vasculature (remodeling, resistance).
- Discussion of MRI's role in evaluating cardiac function (ventricular morphology and function) associated with pulmonary hypertension in BPD.
Main Results:
- Advanced MRI enables comprehensive, non-invasive assessment of BPD's parenchymal, airway, and vascular components.
- MRI can evaluate lung structure, ventilation, perfusion, airway abnormalities, vascular remodeling, and cardiac function.
- Imaging-based phenotyping offers detailed insights into disease complexity and progression.
Conclusions:
- Advanced MRI is a powerful tool for characterizing the multifaceted phenotypes of Bronchopulmonary dysplasia (BPD).
- Non-invasive imaging facilitates a deeper understanding of BPD's impact on lung development, airways, and pulmonary vasculature.
- Imaging-based phenotyping holds significant promise for tailoring management and improving outcomes for infants with BPD.
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