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Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Determinants of Bacterial Pathogenicity and Virulence01:20

Determinants of Bacterial Pathogenicity and Virulence

Pathogenic bacteria employ a variety of strategies to establish infections, including the secretion of extracellular enzymes that act as potent virulence factors. These enzymes facilitate bacterial colonization of host tissues and help evade immune surveillance. By targeting structural components of host tissues and interfering with immune mechanisms, these enzymes play a pivotal role in disease progression.Extracellular Enzymes Facilitating Tissue Invasion: Several bacterial pathogens secrete...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Updated: Jun 18, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Burn Wound Infections With Staphylococcus aureus: Clinical Characteristics and Risk Factors for Methicillin-Resistant

Xiaolan Hong1, Shaobo Zhou1, Qinghua Cai1

  • 1Department of Clinical Laboratory, The 910th Hospital of the Chinese People's Liberation Army Joint Logistics Support Force, Quanzhou, Fujian, China.

International Wound Journal
|June 16, 2026
PubMed
Summary
This summary is machine-generated.

Methicillin-resistant Staphylococcus aureus (MRSA) infections are common in burn patients, with high rates of multidrug resistance. Using three or more antibiotics is a key risk factor for MRSA development in burn wounds.

Keywords:
burn wound infectioninfection controlmethicillin‐resistant S. aureusmultidrug‐resistantrisk factors

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Swine Model of Biofilm Infection and Invisible Wounds
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Swine Model of Biofilm Infection and Invisible Wounds

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Last Updated: Jun 18, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Swine Model of Biofilm Infection and Invisible Wounds
07:16

Swine Model of Biofilm Infection and Invisible Wounds

Published on: June 16, 2023

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Burn Care

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat in healthcare settings, particularly in vulnerable patient populations like burn victims.
  • Understanding the epidemiology and risk factors of MRSA in burn patients is crucial for effective infection control and treatment.

Purpose of the Study:

  • To systematically analyze the clinical features of MRSA infections in burn patients.
  • To identify independent risk factors associated with MRSA development in burn wounds.
  • To inform targeted preventive strategies and therapeutic interventions for MRSA in burn care.

Main Methods:

  • Retrospective analysis of 270 burn patients with Staphylococcus aureus infections (2019-2022).
  • Inclusion of 127 MRSA and 143 methicillin-susceptible S. aureus (MSSA) cases.
  • Statistical analysis, including univariate and multivariate analyses, to identify risk factors.

Main Results:

  • A high prevalence of multidrug-resistant Staphylococcus aureus (68.1%) was observed, with MRSA accounting for 47.0% of infections.
  • The overall MRSA detection rate was 47.0%.
  • Multivariate analysis identified the use of three or more types of antibiotics as an independent risk factor for MRSA infection in burn wounds.

Conclusions:

  • The incidence of multidrug-resistant Staphylococcus aureus, including MRSA, in burn wound infections is notably high.
  • Several factors influence the occurrence of MRSA infections in burn patients.
  • Implementing robust infection control measures is essential to curb the transmission of multidrug-resistant bacteria, such as MRSA.