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Related Concept Videos

Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

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Updated: Jun 18, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Atopic Dermatitis Across the Lifespan: Understanding, Measuring and Minimizing Cumulative Life Course Impairment.

Matthias Augustin1, Paolo Amerio2, Anthony Bewley3

  • 1Institute for Health Services Research in Dermatology and Nursing, University of Hamburg-Eppendorf, Hamburg, Germany. m.augustin@uke.de.

Acta Dermato-Venereologica
|June 17, 2026
PubMed
Summary

Atopic dermatitis (AD) causes significant lifelong impairment, impacting quality of life from childhood. A new questionnaire is needed to assess cumulative life course impairment (CLCI) in pediatric patients.

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Last Updated: Jun 18, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Area of Science:

  • Dermatology
  • Pediatrics
  • Public Health

Background:

  • Atopic dermatitis (AD) imposes a substantial, lifelong burden on patients, beginning in infancy.
  • Beyond physical symptoms like itch and pain, AD significantly diminishes health-related quality of life.
  • Associated conditions contribute to cumulative life course impairment (CLCI), affecting physical, mental, developmental, social, and productive aspects of life.

Purpose of the Study:

  • To highlight the need for a dedicated instrument to assess CLCI in children and adolescents with AD.
  • To raise awareness among healthcare professionals, caregivers, and patients about the lifelong consequences of AD.
  • To improve clinical practice by facilitating risk identification, measurement, and intervention for CLCI.

Main Methods:

  • This paper discusses the necessity and rationale for developing a new assessment tool.
  • It reviews the existing literature on the impact of AD across the lifespan.
  • It emphasizes the importance of a structured questionnaire for pediatric populations.

Main Results:

  • A significant gap exists in assessing CLCI specifically in pediatric AD patients.
  • Existing tools are not tailored for children and adolescents, limiting comprehensive understanding.
  • A new questionnaire could enhance early identification and management of long-term AD effects.

Conclusions:

  • Developing a pediatric CLCI questionnaire is crucial for understanding and mitigating the lifelong impact of AD.
  • Such a tool can improve shared decision-making and treatment conversations.
  • Addressing CLCI in children and adolescents is essential for altering AD trajectories and improving long-term outcomes.