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Related Concept Videos

Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...

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Related Experiment Video

Updated: Jun 18, 2026

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

Multi-target Agents in Complex Diseases: From Design Principles to Therapeutic Applications.

Swastika Maity1, Mahendra Gowdru Srinivas2, Geetha Nayak3

  • 1Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.

Current Drug Targets
|June 17, 2026
PubMed
Summary
This summary is machine-generated.

Multi-target therapies overcome drug resistance in complex diseases by inhibiting multiple biological targets. Emerging technologies like AI and quantum computing promise more effective treatments for conditions such as cancer and neurodegeneration.

Keywords:
Multi-target agentsbiological networkscomplex diseasesdrug discovery.network biologypolypharmacologysingle-target drugs

Related Experiment Videos

Last Updated: Jun 18, 2026

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

Area of Science:

  • Pharmacology
  • Systems Biology
  • Computational Biology

Background:

  • Complex diseases like cancer and neurodegeneration are poorly treated by single-target therapies due to biological network redundancy and adaptive resistance.
  • Traditional monotherapies often fail against multifactorial diseases, necessitating novel therapeutic strategies.

Purpose of the Study:

  • To review the theoretical basis, design approaches, and clinical applications of multi-target agents.
  • To explore the role of network pharmacology and systems biology in developing multi-target therapies.

Main Methods:

  • Comprehensive literature review.
  • Analysis of multi-target agent design strategies (pharmacophore linking, fusing, merging).
  • Investigation of network pharmacology and systems biology applications.

Main Results:

  • FDA-approved multi-kinase inhibitors demonstrate superior efficacy in cancer by inhibiting multiple drivers.
  • Dual inhibitors show promise for Alzheimer's disease neuroprotection.
  • Beta-lactam/beta-lactamase combinations combat drug resistance.
  • Artificial intelligence (AI) and fragment-based screening accelerate target identification and polypharmacology.

Conclusions:

  • Multi-target strategies are crucial for overcoming biological redundancy and drug resistance.
  • Challenges include target selection, balanced efficacy, ADMET optimization, and regulatory hurdles.
  • Emerging technologies (AI, quantum computing, multiomics) offer potential solutions for advanced multi-target interventions.