Palladium Schiff Base Complex-Modified Ti (MIL-125) Metal-Organic Frameworks as an Efficient Catalyst for Asymmetric...

This work presents the design, synthesis, and catalytic evaluation of a novel heterogeneous organometallic catalyst, fabricated through the immobilization of a palladium-Schiff base complex onto the amino-functionalized titanium-based metal-organic framework, NH₂-MIL-125. The resulting composite material was thoroughly characterized using a suite of analytical techniques, including FT-IR, XRD, FE-SEM, TGA, ICP-OES, EDS, and BET surface area analysis, confirming the successful modification and preservation of the MOF architecture. The catalyst demonstrated exceptional performance in facilitating asymmetric Suzuki-Miyaura cross-coupling reactions, proving to be both highly active and stereoselective. The enantiomeric excess (e.e.) of the produced axially chiral biaryls was quantified via high-performance liquid chromatography (HPLC) employing chiral stationary phases. Remarkably, the catalyst afforded biaryl derivatives with excellent enantioselectivity, achieving values up to 95% e.e. These findings underscore the potential of this MOF-based organopalladium nanocomposite as an efficient, reusable, and selective heterogeneous catalyst for the sustainable synthesis of valuable enantiomerically enriched biaryl compounds.