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Related Experiment Video

Updated: Jun 18, 2026

Exploring the Application of Surface-enhanced Raman Scattering-based Biosensing of Individual sEVs in Disease Diagnosis and Therapeutics
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Published on: March 13, 2026

Dual-Modulation of Charge Transfer in Surface-Enhanced Raman Scattering for Qualitative and Quantitative Exosome

Yasheng Dai1, Wenxin Lin1, Qiguang Wang1

  • 1Translational Research Laboratory for Urology, Department of Urology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315010, China.

ACS Sensors
|June 17, 2026
PubMed
Summary

This study introduces a novel photoelectric platform for ultrasensitive surface-enhanced Raman scattering (SERS) bioanalysis. The platform dynamically modulates charge transfer, significantly enhancing detection sensitivity for exosomes.

Keywords:
cancer-derived exosomecharge transferchemical enhancementdual-modulation approachpiezoelectric effectsurface-enhanced Raman scattering

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Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Biotechnology

Background:

  • Conventional semiconductor substrates for surface-enhanced Raman scattering (SERS) face limitations due to static charge-transfer processes.
  • Developing methods for dynamic modulation of photoinduced charge transfer (PICT) is crucial for advancing SERS bioanalysis.

Purpose of the Study:

  • To propose and demonstrate a multifunctional photoelectric platform for ultrasensitive SERS bioanalysis.
  • To achieve dynamic dual-modulation of PICT for enhanced SERS performance.

Main Methods:

  • Utilized a polyvinylidene fluoride (PVDF) matrix for piezoelectric regulation upon mechanical stimulation.
  • Employed NaGdF4@Au nanoprobes with near-infrared excitation for anti-Stokes emission.
  • Integrated piezoelectric and photonic mechanisms for cooperative SERS enhancement.

Main Results:

  • Achieved a nearly 10-fold enhancement factor (EF) under 3 N pressure via piezoelectric regulation.
  • Demonstrated ultrasensitive detection of exosomes as low as 40 particles/mL.
  • Enabled highly accurate classification (≥98%) of cancer-derived exosomes.

Conclusions:

  • The developed platform offers a promising approach for regulated SERS with broad bioanalytical potential.
  • The cooperative piezoelectric-photonic mechanism significantly boosts SERS sensitivity and specificity.
  • This work paves the way for advanced SERS applications beyond exosome detection.