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Natural Plant Extracts Rescue Memory Deficits in Drosophila Neurodegeneration Models.

Jiun Sang¹, Yueyang Kang¹, Youngseok Lee¹

¹Department of Integrative Biotechnology, Kookmin University, Seoul 02707, Republic of Korea.

Journal of Microbiology and Biotechnology

|June 17, 2026

Summary

Nicaraguan plant extracts show neuroprotective potential in fruit fly models of neurodegenerative disease. Three extracts improved memory and stress resilience, with Morisonia incana showing promise for cellular resilience.

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Area of Science:

Neuroscience
Pharmacology
Genetics

Background:

Neurodegenerative diseases cause progressive cognitive, behavioral, and stress resilience impairments.
Current therapeutic interventions for neurodegenerative diseases are limited.
Functional screening of natural products offers a promising avenue for discovering neuroprotective agents.

Purpose of the Study:

To identify Nicaraguan plant extracts with neuroprotective potential using Drosophila melanogaster models of neurodegeneration.
To evaluate the effects of plant extracts on memory, oxidative stress resistance, sleep, and locomotor performance.
To determine the genotype-dependent efficacy of plant extracts in neurodegenerative models.

Main Methods:

Functional screening of Nicaraguan plant extracts in Drosophila melanogaster models (Appl and DJ-1β mutants).

Keywords:

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Multi-assay pipeline including memory testing, oxidative stress survival assays, sleep analysis, and locomotor performance.

mRNA expression profiling was also conducted.

Main Results:

Three extracts (Casearia corymbosa, Xylosma flexuosa, Morisonia incana) significantly improved memory in DJ-1β mutants.
Partial memory recovery was observed in Appl mutants, indicating genotype-dependent effects.
All three extracts enhanced survival under oxidative stress in both mutant models, while sleep defects were not rescued.

Conclusions:

Nicaraguan plant extracts exert selective effects on cognitive function and oxidative stress resistance in neurodegenerative models.
Morisonia incana shows particular promise for enhancing cellular stress resilience in neurodegenerative contexts.
Drosophila-based screening is effective for identifying plant-derived compounds with targeted neuroprotective capabilities.