Related Experiment Video

Updated: Jun 18, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

Aortic Stenosis and Heart Failure With Preserved Ejection Fraction: A Cautionary Tale of Common Partners

Jennifer Y Zhou1,2,3, Shane Nanayakkara1,2,3, David M Kaye1,2,3,4

  • 1Department of Cardiology, Alfred Hospital, Melbourne, Australia (J.Y.Z., S.N., D.M.K., D.S.).

Circulation. Heart Failure
|June 17, 2026
PubMed

Insights

Aortic stenosis (AS) and heart failure with preserved ejection fraction (HFpEF) often coexist, complicating diagnosis and treatment. Understanding their interaction is crucial for managing these prevalent conditions in aging populations.

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Aortic stenosis (AS) involves more than just valve obstruction, affecting the myocardium and leading to extra-valvular abnormalities.
  • These abnormalities, including left ventricular hypertrophy and diastolic dysfunction, resemble heart failure with preserved ejection fraction (HFpEF).
  • AS and HFpEF frequently coexist, particularly in aging populations, sharing risk factors and leading to complex phenotypes.

Purpose of the Study:

  • To review the epidemiological, pathophysiological, and clinical evidence on the overlap between aortic stenosis and HFpEF.
  • To synthesize current understanding of how AS and HFpEF interact and influence each other.
  • To outline the implications of this overlap for diagnosis, prognosis, and patient management.

Main Methods:

  • Literature review integrating epidemiological, pathophysiological, and clinical data.
  • Synthesis of emerging evidence on the AS-HFpEF relationship.
  • Analysis of shared risk factors and convergent phenotypes.

Main Results:

  • AS and HFpEF share extra-valvular abnormalities and risk factors, leading to overlapping clinical presentations.
  • Coexistence of AS and HFpEF complicates diagnosis and treatment response.
  • Residual HFpEF impacts outcomes post-aortic valve replacement, and AS worsens outcomes in HFpEF patients.
  • HFpEF-directed therapies may benefit selected AS patients.

Conclusions:

  • A comprehensive understanding of the AS-HFpEF overlap is essential for optimizing patient care.
  • Further research is needed to refine diagnostic and therapeutic strategies for patients with both conditions.
  • This review highlights the critical need to consider the interplay between AS and HFpEF in clinical practice.

Keywords:
aortic valve stenosisheart failuremyocardiumsodium-glucose transporter 2 inhibitorstranscatheter aortic valve replacement

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