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Related Concept Videos

Fast Reactions01:27

Fast Reactions

Fast reactions occurring in times shorter than the time needed to mix reactants pose a unique challenge for investigation. In a liquid-phase continuous-flow system, reactants A and B are swiftly pushed into the mixing chamber, where mixing occurs within 1 ms. The reaction mixture then flows through an observation tube, and one measures light absorption to determine species concentrations at various points of the tube. This method is most appropriate when relatively large volumes of reactants...

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Related Experiment Video

Updated: Jun 18, 2026

Optimizing the Use of a Liquid Handling Robot to Conduct a High Throughput Forward Chemical Genetics Screen of Arabidopsis thaliana
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Development of a High-Throughput Experimentation Workflow for Photochemical Reaction Screening.

Nam Nguyen1, Colin Masui1, Adam Childs1

  • 1Synthetic Molecule Analytical Chemistry, Synthetic Molecule Pharmaceutical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.

ACS Medicinal Chemistry Letters
|June 17, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed a high-throughput photochemistry screening platform using standard lab equipment. This method enables precise temperature control and rapid reaction optimization for medicinal and process chemistry.

Keywords:
96-well platehigh-throughput experimentationphotochemistryphotoredoxreaction optimization

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Area of Science:

  • Chemistry
  • Chemical Engineering
  • Biotechnology

Background:

  • Photochemistry is crucial for synthesizing novel compounds.
  • High-throughput experimentation (HTE) accelerates reaction optimization.
  • Integrating photochemistry into HTE formats presents unique challenges.

Purpose of the Study:

  • To develop a versatile, high-throughput platform for visible-range photochemistry.
  • To achieve precise temperature control and maximal throughput in photochemical screening.
  • To benchmark the developed platform against existing commercial options.

Main Methods:

  • Integration of commercially available lab equipment into a 96-well screening format.
  • Implementation of magnetic stirring for reaction mixtures.
  • Strategic positioning of light sources above and cooling sources below reaction plates for temperature control.
  • Benchmarking using the Doyle-MacMillan reaction.

Main Results:

  • Successful integration of standard lab equipment for visible-range photochemistry.
  • Achieved precise temperature control and high throughput in a 96-well format.
  • Demonstrated platform's efficacy through benchmarking against state-of-the-art commercial options.

Conclusions:

  • A highly irradiated, temperature-controlled micromole-scale HTE protocol for photochemistry was established.
  • This platform can accelerate reaction optimization in medicinal and process chemistry.
  • The developed system offers a cost-effective and efficient solution for photochemical screening.