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Controlling Neuroplasticity Across Scales: Constrained Serotonergic Agonists, Neuroplastogens, and Adaptive
Anna C Renner1, Robert B Kargbo2
1North Dakota State University, Fargo, North Dakota 58108-6050, United States.
Abstract:
Recent advances in serotonergic drug discovery and neuromodulation converge on a central goal: inducing therapeutic neuroplasticity without undesirable perceptual effects. Structurally constrained receptor agonists, biologically validated neuroplastogens, and adaptive transcutaneous stimulation systems together define a multiscale framework that integrates molecular precision, cellular remodeling, and physiological regulation, enabling controlled and reproducible neuropsychiatric treatment outcomes.
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