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Published on: September 27, 2024
Glioblastoma Multiforme: Current Developments in Molecular Pathways, Magnetic Field-Based Interventions, and
Emel Çolak1, Ravza Tosunbayraktar1, Sacide Sarıçiçek1
1Department of Neuroscience, Erciyes University Gevher Nesibe Genome and Stem Cell Institute, Kayseri, Türkiye.
Journal of Clinical Practice and Research
|June 17, 2026
Summary
Magnetic field therapy shows promise for treating glioblastoma multiforme (GBM), the most aggressive brain cancer. Low-frequency magnetic fields and static magnetic fields may suppress glioma cell proliferation and offer a low-toxicity complementary treatment.
Area of Science:
- Neuro-oncology
- Biophysics
- Cancer research
Background:
- Glioblastoma multiforme (GBM) is an aggressive brain cancer with poor prognosis.
- Treatment is challenging due to resistance, recurrence, and heterogeneity.
- Molecular markers like IDH mutations influence GBM's course and treatment response.
Purpose of the Study:
- To review diagnostic methods, molecular pathogenesis, histopathology, and current treatments for GBM.
- To assess novel therapeutic strategies for glioblastoma multiforme.
- To explore the potential of magnetic field-based interventions in GBM treatment.
Main Methods:
- Review of current literature on GBM diagnostics, molecular markers, and therapies.
- Assessment of studies on magnetic field applications (low-frequency and static) in glioma models.
- Evaluation of synergistic effects with existing therapies like anti-PD-1.
Main Results:
- Magnetic field interventions show potential in suppressing glioma cell proliferation.
- The OM-100 device demonstrated tumor growth reduction in vitro and in vivo.
- Static magnetic fields may increase apoptosis and inhibit proliferation with low toxicity.
Conclusions:
- Magnetic field-based approaches represent an innovative strategy for glioblastoma treatment.
- These methods may offer a complementary, low-toxicity option for GBM patients.
- Further research into magnetic field therapy could lead to improved GBM treatment outcomes.
