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Updated: Jun 18, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
05:36

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

The relationship between RSUME and VHL/HIF-1α signalling pathway in renal cell carcinoma

Yuanliang Wang1, Xin Wang1, Faliang Zhao1

  • 1Departments of Urology, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.

Archives of Medical Science : AMS
|June 17, 2026
PubMed
Abstract

Insights

Human RWD containing sumoylation enhancer (RSUME) is upregulated in renal cell carcinoma (RCC). RSUME may promote RCC progression by interacting with the VHL/HIF-1α pathway, suggesting it as a potential therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Renal cell carcinoma (RCC) is characterized by von Hippel-Lindau (VHL) gene loss, leading to HIF pathway activation and tumor development.
  • Human RWD containing sumoylation enhancer (RSUME) is implicated in pituitary tumors, but its role in RCC is unknown.

Purpose of the Study:

  • To investigate the expression levels of VHL, HIF-1α, and RSUME in human RCC tissues.
  • To analyze the correlations between VHL, HIF-1α, and RSUME in RCC.

Main Methods:

  • Immunohistochemistry was used to detect protein expression levels.
  • Real-time PCR was employed to quantify gene expression levels.
  • Expression was analyzed in normal renal tissue and RCC tissue samples.

Main Results:

  • RSUME and HIF-1α were significantly upregulated in RCC tissues compared to normal tissues (p < 0.05).
  • VHL expression was significantly lower in RCC tissues than in normal tissues (p < 0.05).
  • VHL expression was negatively correlated with HIF-1α and RSUME, while RSUME and HIF-1α showed a positive correlation (p < 0.05).

Conclusions:

  • Upregulated RSUME expression is associated with RCC formation and progression.
  • RSUME may exert its effects through the VHL/HIF-1α signaling pathway.
  • RSUME represents a potential novel therapeutic target for renal cell carcinoma.
Keywords:
HIF-1αVHLhuman RWD-containing sumoylation enhancerrenal cell carcinoma

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