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Curcumin ameliorates ulcerative colitis via inhibiting STAT3-mediated angiogenesis
Su Xu1, Zixuan Zhou2, Aoxun Zhu1
1Yancheng TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Jiangsu, China.
Archives of Medical Science : AMS
|June 17, 2026
Summary
Curcumin effectively treats ulcerative colitis by inhibiting angiogenesis via the VEGF-mediated JAK2/STAT3 pathway. This natural compound shows promise as a novel therapeutic for this inflammatory bowel disease.
Area of Science:
- Gastroenterology
- Molecular Biology
- Pharmacology
Background:
- Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited treatment options.
- Angiogenesis plays a role in UC pathogenesis, presenting a potential therapeutic target.
Purpose of the Study:
- To investigate curcumin's therapeutic effect on UC.
- To determine if curcumin's efficacy correlates with angiogenesis inhibition.
- To elucidate the molecular mechanisms underlying curcumin's action in UC.
Main Methods:
- Multi-database analysis to identify molecular targets.
- In vitro assays (tube formation, aortic ring) to assess angiogenesis.
- In vivo studies using a dextran sulfate sodium (DSS)-induced UC mouse model.
Main Results:
- Curcumin inhibited angiogenesis in vitro by downregulating VEGF and p-STAT3/JAK2.
- Curcumin treatment ameliorated UC symptoms and reduced inflammatory markers (TNF-α, IL-6) in vivo.
- Curcumin suppressed STAT3 and VEGF expression in colonic tissues of UC mice.
Conclusions:
- Curcumin ameliorates ulcerative colitis by inhibiting the VEGF-mediated JAK2/STAT3 signaling pathway.
- Curcumin demonstrates potential as a clinical drug for ulcerative colitis treatment.
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