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Related Concept Videos

The Parathyroid Glands00:59

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
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Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

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Related Experiment Video

Updated: Jun 18, 2026

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
05:47

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Published on: May 10, 2021

Interplay between parathyroid hormone concentration and valvular and aortic calcifications.

Anna Olasińska-Wiśniewska1, Kajetan Grodecki2, Karolina Jemielity3

  • 1Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland.

Archives of Medical Science : AMS
|June 17, 2026
PubMed
Summary

Elevated parathyroid hormone (PTH) levels correlate with increased calcific tissue attenuation in the aorta and heart valves, but not calcium volume. PTH concentration did not predict complications after transcatheter aortic valve implantation (TAVI).

Keywords:
aortic stenosiscalcificationcomputed tomographyparathyroid hormone

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Related Experiment Videos

Last Updated: Jun 18, 2026

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
05:47

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

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Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification
08:55

Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification

Published on: November 20, 2017

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Radiology

Background:

  • Hyperparathyroidism is increasingly linked to cardiovascular disorders.
  • Parathyroid hormone (PTH) may play a role in valvular calcification.
  • Understanding this relationship is crucial for managing valvular heart disease.

Purpose of the Study:

  • To investigate the association between parathyroid hormone (PTH) levels and valvular calcification.
  • To evaluate the relationship between PTH and outcomes following transcatheter aortic valve implantation (TAVI).

Main Methods:

  • Eighty-nine patients with severe symptomatic aortic stenosis undergoing TAVI were studied.
  • Echocardiography and computed tomography (CT) assessed calcific tissue.
  • Semiautomated software quantified calcification in the aorta and heart valves.

Main Results:

  • Increased PTH correlated with higher peak aortic gradient.
  • PTH was associated with greater calcific tissue attenuation in the aortic and mitral valves and ascending aorta.
  • No association was found between PTH and calcium volume or post-TAVI complications like paravalvular leak or pacemaker implantation.

Conclusions:

  • Parathyroid hormone (PTH) influences the attenuation of calcific tissue in degenerated cardiovascular regions, not necessarily the volume.
  • PTH may serve as a biomarker for calcific burden in valvular heart disease.
  • PTH levels do not appear to predict complications after TAVI.