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Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
Published on: May 10, 2021
Interplay between parathyroid hormone concentration and valvular and aortic calcifications.
Anna Olasińska-Wiśniewska1, Kajetan Grodecki2, Karolina Jemielity3
1Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland.
Elevated parathyroid hormone (PTH) levels correlate with increased calcific tissue attenuation in the aorta and heart valves, but not calcium volume. PTH concentration did not predict complications after transcatheter aortic valve implantation (TAVI).
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Radiology
Background:
- Hyperparathyroidism is increasingly linked to cardiovascular disorders.
- Parathyroid hormone (PTH) may play a role in valvular calcification.
- Understanding this relationship is crucial for managing valvular heart disease.
Purpose of the Study:
- To investigate the association between parathyroid hormone (PTH) levels and valvular calcification.
- To evaluate the relationship between PTH and outcomes following transcatheter aortic valve implantation (TAVI).
Main Methods:
- Eighty-nine patients with severe symptomatic aortic stenosis undergoing TAVI were studied.
- Echocardiography and computed tomography (CT) assessed calcific tissue.
- Semiautomated software quantified calcification in the aorta and heart valves.
Main Results:
- Increased PTH correlated with higher peak aortic gradient.
- PTH was associated with greater calcific tissue attenuation in the aortic and mitral valves and ascending aorta.
- No association was found between PTH and calcium volume or post-TAVI complications like paravalvular leak or pacemaker implantation.
Conclusions:
- Parathyroid hormone (PTH) influences the attenuation of calcific tissue in degenerated cardiovascular regions, not necessarily the volume.
- PTH may serve as a biomarker for calcific burden in valvular heart disease.
- PTH levels do not appear to predict complications after TAVI.
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