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Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
Integrated transcriptomics identifies HIF1A and GSTP1 as biomarkers for cutaneous squamous cell carcinoma
Wenting Li1, Tao Xu2,3, Yu Ding2
1Department of Dermatology, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Translational Cancer Research
|June 17, 2026
Summary
New biomarkers HIF1A and GSTP1 show promise for detecting cutaneous squamous cell carcinoma (cSCC). These genes are linked to immune changes and potential drug targets, improving early diagnosis and prognosis for this common skin cancer.
Area of Science:
- Oncology
- Genomics
- Immunology
Background:
- Cutaneous squamous cell carcinoma (cSCC) is a prevalent skin cancer lacking reliable early detection and prognostic biomarkers.
- Understanding cellular and immune alterations in cSCC is crucial for improving patient outcomes.
Purpose of the Study:
- To identify key post-translational modification-related genes in cSCC.
- To characterize cellular and immune landscape changes in cSCC using integrated transcriptomic data.
Main Methods:
- Integrated bulk and single-cell transcriptomic analysis of cSCC datasets.
- Utilized feature selection algorithms and qRT-PCR for candidate gene validation.
- Performed functional analyses including immune infiltration, drug prediction, and intercellular communication analysis.
Main Results:
- Identified keratinocytes as the key cell population in cSCC.
- HIF1A and GSTP1 validated as diagnostic biomarkers with high AUC (>0.7), upregulated in cSCC.
- Discovered correlations between HIF1A/GSTP1, immune cells (macrophages, NK cells, neutrophils), and enhanced cell signaling pathways (VEGF, EDN).
Conclusions:
- HIF1A and GSTP1 are promising diagnostic biomarkers for cSCC.
- These biomarkers are associated with altered immune microenvironments and enhanced intercellular communication.
- Identified potential therapeutic strategies targeting HIF1A and GSTP1 interactions.