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Model-informed safety management of tocilizumab for pediatric sJIA: a PBPK approach for dose-escalation and

Yujie Yang1, Rui Wang2,3, Zhimin Li4

  • 1Department of Pharmacy, Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China.

Frontiers in Immunology
|June 17, 2026
PubMed
Abstract

Keywords:
childrendose escalationphysiologically based pharmacokinetic modelingtocilizumabvaccines

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