Related Experiment Video
Updated: Jun 18, 2026
Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
Patient-derived organoids for personalized drug response profiling and multi-omics integration in oral squamous cell
Pengyu Li1,2, Nenghao Jin1,3, Ning Zhang4
1Department of Stomatology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Abstract:
Oral squamous cell carcinoma (OSCC) exhibits marked interpatient variability in chemotherapy response, with no reliable predictive tools, hindering personalized care. We established a biobank of patient-derived organoids (PDOs) from 10 patients with OSCC, which retained key histopathological and genetic features of primary tumors. These PDOs recapitulated clinical chemotherapy response diversity. Multi-omics analyses (genomics, transcriptomics, drug sensitivity) identified molecular signatures linked to chemotherapy resistance. Critically, PDO drug responses closely matched patients' clinical outcomes, validating their potential to predict treatment efficacy. Additionally, PDOs highlighted targeting the JAK-STAT pathway as a promising strategy to overcome resistance. Our findings support OSCC PDOs as a robust tool to guide personalized treatment decisions and improve OSCC patient outcomes.
