Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acupuncture for Early Parkinson's Motor Symptoms: A Multicenter Randomized Controlled Trial Protocol.

Jiewen Zhang1,2, Yici Xie1,2, Weixin Huang3

  • 1South China Research Center for Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.

Neuropsychiatric Disease and Treatment
|June 17, 2026
PubMed
Summary

Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Study on Vertical Non-Uniformity of Plasma Electrolytic Polishing.

Materials (Basel, Switzerland)·2026
Same author

Spatial organization of the TNBC tumor microenvironment: multicellular niches, T-cell bottlenecks, and therapeutic opportunities.

Journal of translational medicine·2026
Same author

Integrated volatile and non-volatile metabolomics reveal aroma chemotypes in Capsicum cultivars.

Food chemistry: X·2026
Same author

Development of potent BChE/Nrf2 modulators for Alzheimer's disease treatment via dual suppression of ferroptosis.

European journal of medicinal chemistry·2026
Same author

Real-time robust autofocus method enabling sustained intravital scanning light field imaging.

Nature communications·2026
Same author

Repeatability and agreement of planar lumbar range of motion measured by dynamic fluoroscopy and optical motion capture in an ovine cadaveric model.

Frontiers in bioengineering and biotechnology·2026

This study investigates acupuncture for early Parkinson's disease (PD) motor symptoms. The randomized controlled trial aims to clarify acupuncture's efficacy and explore its mechanisms using multi-omics analysis.

Area of Science:

  • Neurology
  • Integrative Medicine
  • Biochemistry

Background:

  • Pharmacological treatments for early Parkinson's disease (PD) face limitations.
  • Acupuncture shows potential as a non-pharmacological therapy for PD motor disorders.
  • High-quality evidence on acupuncture's efficacy in PD is currently lacking.

Purpose of the Study:

  • To clarify the efficacy of acupuncture for early Parkinson's disease (PD) motor symptoms.
  • To explore the underlying mechanisms of acupuncture's therapeutic effects in PD using multi-omics.
  • To provide evidence-based data through a randomized controlled trial (RCT).

Main Methods:

  • A multi-center, blinded, randomized controlled trial (RCT) with 136 participants.
  • Comparison between acupuncture and sham acupuncture groups over 4 weeks (12 sessions).
Keywords:
Parkinsonacupuncturemotorprotocolrandomized controlled trial

Related Experiment Videos

  • Primary outcome: motor function (UPDRS-III); Secondary outcomes: gait, disease stage, quality of life, and metabolomics/proteomics.

    • Main Results:

    • Primary outcome: motor function assessed by UPDRS-III.
    • Secondary outcomes included objective gait metrics, disease staging (Hoehn and Yahr), quality of life (ADL, PDQ-39), and changes in levodopa dosage.
    • Exploratory analyses included LC-MS/MS untargeted metabolomics and deep proteomics.

    Conclusions:

    • The study aims to establish the efficacy of acupuncture for early PD motor symptoms.
    • Investigating molecular mechanisms through multi-omics will provide deeper insights.
    • Results will contribute evidence-based data to the field of complementary and alternative medicine for PD.