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The fourth controlled release society workshop on oral peptide administration
David J Brayden1, Stephen T Buckley2, Andrew L Lewis3
1Advanced Drug Delivery, University College Dublin, Dublin, Ireland.
Frontiers in Drug Delivery
|June 17, 2026
Summary
The Controlled Release Society workshop focused on oral peptide delivery advancements. Experts discussed clinical programs, permeation enhancers, and challenges in bringing oral peptide drugs to market.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery
- Biotechnology
Background:
- The Controlled Release Society (CRS) convened its fourth workshop on oral peptide administration.
- This topic remains critical due to ongoing technical and commercial challenges in oral peptide product development.
- Previous CRS workshops were held in 2008, 2014, and 2023, highlighting sustained scientific interest.
Purpose of the Study:
- To provide an update on current clinical oral peptide programs.
- To discuss mechanistic progress in the development of permeation enhancers for oral delivery.
- To evaluate limitations of preclinical bioassays and animal models in oral peptide drug development.
Main Methods:
- The workshop featured nine expert talks and two roundtable discussions.
- Presentations covered recent advances in oral peptide delivery, from molecule to market.
- Discussions focused on clinical progress, enhancer mechanisms, and preclinical model limitations.
Main Results:
- The workshop successfully updated attendees on the latest clinical oral peptide programs.
- Mechanistic insights into permeation enhancers were shared.
- Limitations and areas for improvement in preclinical bioassays and animal models were identified.
Conclusions:
- Oral peptide delivery is a dynamic field with significant ongoing research and development.
- Addressing challenges in permeation enhancement and preclinical modeling is crucial for future success.
- Continued collaboration and knowledge sharing are vital for advancing oral peptide therapeutics.
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