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LiMeNEx: an interactive webserver on lipid biochemical gene-regulatory network
Diksha Marwaha1, Aishwary Sharma1, Kartikeya Saini1
1Department of Computational Biology, Indraprastha Institute of Information Technology Delhi (IIIT-Delhi), Okhla Industrial Estate, Phase III, New Delhi 110020, India.
Nucleic Acids Research
|June 17, 2026
Summary
LiMeNEx is a new webserver that explores lipid metabolism by integrating biochemical reactions with gene regulatory networks. It helps researchers investigate lipid imbalance and related diseases across human tissues and physiological systems.
Area of Science:
- Biochemistry
- Systems Biology
- Bioinformatics
Background:
- Lipid metabolism is crucial for health, involving complex enzymatic and transcriptional regulation.
- Disruptions in lipid metabolism are linked to various diseases.
- Current resources lack integrated views of metabolic pathways and regulatory networks.
Purpose of the Study:
- To develop LiMeNEx, an interactive webserver for exploring lipid biochemical gene regulatory networks.
- To integrate metabolic and regulatory layers for system-level analysis of lipid metabolism.
- To facilitate investigation of lipid-associated mechanisms and disorders.
Main Methods:
- Developed LiMeNEx, a webserver integrating 504 biochemical reactions, 330 enzymatic genes, and 345 transcription factors.
- Mapped data across 50 human tissues and 11 physiological systems.
- Implemented interactive query functionalities for lipids, genes, and tissue-specific regulators.
Main Results:
- LiMeNEx provides a holistic view of lipid metabolism by linking lipids, enzymes, and transcription factors.
- The webserver visualizes lipid pathways, enzyme reactions, and tissue-specific transcriptional regulators.
- It offers comprehensive documentation for intuitive navigation and system-level investigation.
Conclusions:
- LiMeNEx enables hypothesis-driven research into lipid metabolism and associated diseases.
- The integration of metabolic and regulatory data in a tissue-resolved framework is a key advancement.
- LiMeNEx supports a deeper understanding of lipid homeostasis and pathophysiology.
