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Related Concept Videos

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then passed on to...
Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle01:19

Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle

Inductively coupled plasma (ICP) is the most widely used plasma source in atomic emission spectroscopy (AES), also known as Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). The ICP source, or torch, consists of three concentric quartz tubes with argon gas flowing through them. A spark from a Tesla coil initiates the ionization of argon, generating a high-temperature plasma.
The ions and electrons produced interact with the fluctuating magnetic field created by a water-cooled...
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences01:20

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences

Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and refractory oxide ion...
Atomic Emission Spectroscopy: Lab01:29

Atomic Emission Spectroscopy: Lab

AES is a powerful analytical technique, especially effective when used with plasma sources, producing abundant spectra in characteristic emission lines. The Inductively Coupled Plasma (ICP), in particular, yields superior quantitative analytical data due to its high stability, low noise, low background, and minimal interferences under optimal experimental conditions. However, newer air-operated microwave sources are emerging as promising alternatives that could be more cost-effective than...
Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation01:26

Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation

Inductively coupled plasma (ICP) is the common plasma source used in atomic emission spectroscopy (AES), a technique that detects and analyzes various elements in a sample. This method is often called inductively coupled plasma atomic emission spectroscopy (ICP-AES).
There are three main types of inductively coupled plasma atomic emission spectroscopy  (ICP-AES) instruments: sequential, simultaneous multichannel, and Fourier transform instruments, with the latter being less commonly used.

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Updated: Jun 18, 2026

In Situ Detection and Single Cell Quantification of Metal Oxide Nanoparticles Using Nuclear Microprobe Analysis
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High Spatial Resolution In Situ Fe Isotope Analysis by Laser Ablation Collision/Reaction Cell MC-ICP-MS: Application

Xianli Zeng1, Jun Cao2, Qi He1

  • 1State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan 430074, China.

Analytical Chemistry
|June 17, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces a new femtosecond laser ablation collision/reaction cell (LA-CRC) method for high-resolution iron (Fe) isotope analysis. This advanced technique significantly improves spatial resolution and sensitivity, enabling detailed studies of geological and extraterrestrial materials.

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Quantitative Atomic-Site Analysis of Functional Dopants/Point Defects in Crystalline Materials by Electron-Channeling-Enhanced Microanalysis
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Last Updated: Jun 18, 2026

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Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry (LA-ICP-MS)
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Quantitative Atomic-Site Analysis of Functional Dopants/Point Defects in Crystalline Materials by Electron-Channeling-Enhanced Microanalysis
07:24

Quantitative Atomic-Site Analysis of Functional Dopants/Point Defects in Crystalline Materials by Electron-Channeling-Enhanced Microanalysis

Published on: May 10, 2021

Area of Science:

  • Geochemistry and Cosmochemistry
  • Analytical Chemistry
  • Mass Spectrometry

Background:

  • Iron (Fe) isotopes are crucial tracers for geological and extraterrestrial material analysis.
  • Conventional laser ablation multicollector inductively coupled plasma mass spectrometry (LA-MC-ICP-MS) for in situ Fe isotope analysis faces limitations due to interferences and low sensitivity.
  • These limitations hinder the investigation of intragrain variability and fine-grained extraterrestrial samples.

Purpose of the Study:

  • To develop a novel method for high spatial resolution in situ Fe isotope analysis.
  • To overcome the limitations of existing LA-MC-ICP-MS techniques for Fe isotope measurements.
  • To enable detailed analysis of Fe isotope heterogeneity in fine-grained and complex samples, including lunar materials.

Main Methods:

  • Femtosecond laser ablation coupled with a collision/reaction cell (LA-CRC) and multicollector inductively coupled plasma mass spectrometry (MC-ICP-MS).
  • Utilized a hydrogen (H2)-helium (He) gas mixture in the CRC to suppress argon (Ar)-based interferences.
  • Employed a 1028 nm infrared laser for enhanced ablation rates and optimized analytical conditions for increased sensitivity (>50-fold).

Main Results:

  • The developed LA-CRC-MC-ICP-MS method effectively suppressed Ar-based interferences, allowing accurate Fe isotope analysis in low-resolution mode.
  • Achieved a >50-fold increase in Fe isotope sensitivity compared to conventional LA-MC-ICP-MS.
  • Demonstrated high spatial resolution (8-15 μm beam spots) with excellent reproducibility (0.09‰-0.15‰, 2SD) on various Fe-bearing materials.
  • Successfully applied the method to Chang'e-6 lunar samples, revealing significant intraparticle Fe isotope variability at micrometer scales.

Conclusions:

  • The femtosecond LA-CRC-MC-ICP-MS technique provides unprecedented spatial resolution for Fe isotope microanalysis, improving it by 1-2 orders of magnitude.
  • This method effectively resolves Fe isotope heterogeneity in fine-grained and complex geological and extraterrestrial samples.
  • The technique holds significant potential for advancing isotope geochemistry, particularly in the analysis of planetary samples.