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Related Experiment Video

Updated: Jun 29, 2026

Isolation, Processing and Analysis of Murine Gingival Cells
09:47

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

Identifying Shared Key Genes and Cellular Characteristics Between Chronic Periodontitis and Aging Using Integrative

Fengzhen Lei1, Rui Shi2, Qiuli Chen1

  • 1Department of Stomatology, Shenzhen Longhua District Central Hospital, Shenzhen, China, glyy.org.

Biomed Research International
|June 17, 2026
PubMed
Summary
This summary is machine-generated.

Chronic periodontitis (CP) and aging share downregulated CD8_CM T cells. Genes GZMK, KLRG1, and LYAR may link these conditions, offering insights into shared mechanisms.

Keywords:
MRagingchronic periodontitissingle-cell

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Last Updated: Jun 29, 2026

Isolation, Processing and Analysis of Murine Gingival Cells
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Published on: July 2, 2013

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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Area of Science:

  • Immunology
  • Genetics
  • Gerontology

Background:

  • Chronic periodontitis (CP) and aging are prevalent conditions with complex underlying mechanisms.
  • Identifying shared molecular pathways could reveal novel therapeutic targets for both aging and CP.

Purpose of the Study:

  • To investigate shared key genes and cellular mechanisms between chronic periodontitis (CP) and aging.
  • To explore the causal relationship between aging and CP susceptibility.

Main Methods:

  • Single-cell RNA sequencing (scRNA-seq) of peripheral blood from CP patients, aging individuals, and healthy controls.
  • Pseudotime trajectory analysis, intercellular communication modeling, Mendelian randomization (MR), and colocalization analysis.
  • Genome-wide association studies (GWAS) and expression quantitative trait locus (eQTL) data integration.

Main Results:

  • T cell subsets, specifically CD8_CM cells, were downregulated in both CP and aging groups.
  • Sixteen differentially expressed genes were identified, with GZMK, KLRG1, and LYAR showing causal relationships with aging and CP.
  • Limited evidence for shared causal variants was found, but metabolic pathway enrichment analysis identified associated pathways.

Conclusions:

  • Downregulation of CD8_CM cells is a shared feature of CP and aging.
  • GZMK, KLRG1, and LYAR are potential molecular links between aging and CP.
  • This study provides novel insights into the intersection mechanisms of aging and CP.