Related Experiment Video

Updated: Jun 18, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness

Published on: May 3, 2018

Long-term prognostic impact of a novel arterial stiffness index using upper-arm cuff oscillometric inflation

Noriyuki Kawaura1, Rie Nakashima-Sasaki1, Kotaro Uchida1

  • 1Department of Cardiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Journal of Hypertension
|June 17, 2026
PubMed

Insights

Arterial stiffness indices, arterial pressure volume index (API) and arterial velocity pulse index (AVI), effectively predict long-term outcomes in patients at risk for arteriosclerosis. These noninvasive measures offer valuable prognostic insights for cardiovascular event prevention.

Area of Science:

  • Cardiovascular research
  • Vascular diagnostics
  • Predictive analytics in medicine

Background:

  • Arteriosclerosis is a primary driver of cardiovascular events, necessitating advanced predictive tools for prevention.
  • The AVE-1500 device offers noninvasive measurement of arterial stiffness and central pressure via arterial pressure volume index (API) and arterial velocity pulse index (AVI).

Purpose of the Study:

  • To evaluate the long-term prognostic significance of the novel noninvasive vascular indices, API and AVI.
  • To assess the predictive value of these indices in a diverse outpatient population at risk for arteriosclerosis.

Main Methods:

  • A retrospective, single-center, observational cohort study involving 230 outpatients with varied clinical profiles.
  • Patients were followed for an average of 2473 days, with stratification based on API (≤ 32.0 vs. > 32.0) and AVI (≤ 27.0 vs. > 27.0).
  • Kaplan-Meier survival analysis was employed to assess outcomes.

Main Results:

  • Significant differences in all-cause mortality, cardiovascular events, and a composite endpoint were observed between patient groups stratified by API and AVI.
  • Mean API was 32.5 and mean AVI was 23.9 in the study cohort.

Conclusions:

  • The study demonstrates that API and AVI possess significant long-term prognostic value.
  • These noninvasive vascular indices are valuable tools for risk stratification in patients susceptible to arteriosclerosis.
Abstract

Keywords:
arterial pressure volume indexarterial stiffnessarterial velocity pulse indexprognosis

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