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Clinical Pharmacist Intervention Improves Adherence to Venous Thromboembolism Protocols
Anne Karollyne Soares Silva Leite1, Leiliane Rodrigues Marcatto2, Pedro Eduardo Nascimento Silva Vasconcelos1
1Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo, EPM-Unifesp, São Paulo, Brazil.
Pharmacoepidemiology and Drug Safety
|June 17, 2026
Summary
Clinical pharmacists improved venous thromboembolism (VTE) prophylaxis adherence in hospitalized patients. Their interventions enhanced the appropriate use of VTE preventive measures in both clinical and surgical settings.
Area of Science:
- Pharmacology
- Healthcare Management
- Patient Safety
Background:
- Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in hospitalized individuals.
- Risk assessment scores are recommended for VTE prophylaxis, but challenges remain in implementation.
- Clinical pharmacists can play a crucial role in optimizing VTE prevention strategies.
Purpose of the Study:
- To evaluate the impact of clinical pharmacist interventions on VTE prophylaxis.
- To assess the contribution of pharmacists to the appropriate indication and use of VTE prophylaxis.
- To analyze VTE prophylaxis in a large cohort of clinical and surgical patients.
Main Methods:
- Observational, retrospective study utilizing hospital data.
- Inclusion of 4031 patients (1093 clinical, 2938 surgical).
- Evaluation of pharmacist interventions on VTE prophylaxis adequacy.
Main Results:
- 262 pharmacist interventions were recorded.
- Improvements in VTE prophylaxis adequacy rates were observed: 62.0% for clinical patients and 55.0% for surgical patients.
- Pharmacist involvement correlated with better prophylaxis outcomes.
Conclusions:
- Clinical pharmacist intervention significantly contributes to improved adherence to VTE prophylaxis protocols.
- Pharmacist-led initiatives can enhance patient safety by optimizing VTE prevention.
- The study highlights the value of clinical pharmacists in managing VTE risk in hospitals.
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