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Updated: Jun 18, 2026
04:40
Venous Thrombosis Assay in a Mouse Model of Cancer
Published on: January 5, 2024
Upper Extremity Deep Vein Thrombosis in Cancer Patients: Clinical Course by Cancer Site
Olivier Espitia1, Alexis F Guedon2, Emma Courouve1
1Department of Internal and Vascular Medicine, Nantes Université, CHU Nantes, l'Institut du Thorax, INSERM UMR 1087/CNRS UMR 6291, Team III Vascular & Pulmonary Diseases, Nantes, France.
JACC. Cardiooncology
|June 17, 2026
Summary
Patients with cancer-related upper extremity deep vein thrombosis (UEDVT) face higher risks of recurrence and bleeding. Extended anticoagulation beyond 90 days significantly reduces post-treatment recurrence, particularly for lung cancer patients.
Area of Science:
- Vascular Medicine
- Oncology
- Hematology
Background:
- Upper extremity deep vein thrombosis (UEDVT) is a frequent complication in cancer patients.
- Limited data exist regarding recurrence and bleeding risks associated with cancer-related UEDVT.
Purpose of the Study:
- To identify factors influencing venous thromboembolism (VTE) recurrence and bleeding in cancer patients with UEDVT.
- To analyze these factors during and after anticoagulation therapy, considering different cancer types.
Main Methods:
- Analysis of data from the prospective, observational RIETE registry.
- Estimation of cumulative incidence functions for recurrence and bleeding at 6, 12, 18, and 24 months.
- Application of proportional subdistribution hazard models to assess risk factors.
Main Results:
- Cancer patients with UEDVT showed significantly higher 24-month recurrence (3.9%) and bleeding (6.8%) rates compared to non-cancer patients (2.5% and 4.3%, respectively).
- Lung cancer (6.4%) had the highest recurrence rate; genitourinary cancer was linked to increased bleeding risk.
- During anticoagulation, lung cancer and younger age were associated with recurrence; post-discontinuation, longer anticoagulation duration (91-180 days, >180 days) correlated with lower recurrence.
Conclusions:
- Cancer-associated UEDVT presents elevated risks for recurrence and bleeding compared to non-cancer UEDVT.
- Lung cancer is associated with the highest recurrence risk during treatment.
- Anticoagulation extending beyond 90 days is linked to reduced recurrence after treatment cessation.
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