Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 18, 2026

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
15:48

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

CanAssist Breast Risk Stratification in Multifocal/Multicentric Breast Cancer: To Test Each Focus or Not?

Badada Ananthamurthy Savitha, Tejal Deepak Durgekar, Payal Shrivastava

    Archives of Pathology & Laboratory Medicine
    |June 17, 2026
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Benzazepines Derivatives: Synthetic Strategy, Structural-Activity Relationships, and Medical Potential as Dopamine and Serotonin Receptor Modulators.

    ACS omega·2026
    Same author

    Rapid Transcription Dynamics Confers Cytarabine Resistance in Acute Myeloid Leukemia.

    Blood cancer discovery·2026
    Same author

    Synthesis and Biological Activity of Guanidine Scaffold: A Comprehensive Review.

    Anti-inflammatory & anti-allergy agents in medicinal chemistry·2026
    Same author

    Pseudo-autologous Stem Cell Transplant for the Treatment of Secondary Central Nervous System Lymphoma.

    Cureus·2026
    Same author

    Chromatin rewiring of β-globin and MYC enhancers by TGF-β1 drives defective erythropoiesis.

    Nature communications·2026
    Same author

    Appropriate Use of Mohs Micrographic Surgery: A Survey of Australasian Mohs Dermatologists.

    The Australasian journal of dermatology·2026
    Same journal

    Accuracy of Cytology Diagnosis for Well Differentiated Neuroendocrine Tumors: Assessment by the College of American Pathologists Non-Gynecologic Slide Program.

    Archives of pathology & laboratory medicine·2026
    Same journal

    Serum Immunofixation Electrophoresis Guidance Conflict: A Call to Harmonize.

    Archives of pathology & laboratory medicine·2026
    Same journal

    In Reply.

    Archives of pathology & laboratory medicine·2026
    Same journal

    Journal Club and Artificial Intelligence.

    Archives of pathology & laboratory medicine·2026
    Same journal

    In Reply.

    Archives of pathology & laboratory medicine·2026
    Same journal

    Using R Statistical Programming to Evaluate the Impact of the Lower Anogenital Squamous Terminology Recommendations on Cervical Biopsy Reporting at a Tertiary Care Academic Center.

    Archives of pathology & laboratory medicine·2026
    See all related articles

    Multifocal/multicentric breast cancer (MF/MC BC) requires careful prognostic testing. The CanAssist Breast (CAB) test shows intertumoral heterogeneity, guiding a tiered approach for better treatment planning.

    Area of Science:

    • Oncology
    • Genomics
    • Artificial Intelligence

    Background:

    • Multifocal/multicentric breast cancer (MF/MC BC) lacks clear prognostic testing guidelines, impacting adjuvant treatment decisions.
    • CanAssist Breast (CAB) is an AI-based proteomic test assessing distant recurrence risk in HR+/HER2- early breast cancer.

    Purpose of the Study:

    • To evaluate the CAB test's ability to stratify recurrence risk in MF/MC BC.
    • To assess the utility of CAB testing in guiding adjuvant chemotherapy recommendations for MF/MC BC.

    Main Methods:

    • Retrospective analysis of 6126 patients with HR+/HER2- early breast cancer undergoing CAB testing.
    • Focused study on 107 MF/MC BC patients with CAB testing on multiple tumor foci.
    • Evaluation of concordance and discordance in CAB risk categories across multiple foci.

    More Related Videos

    Long-term Culture of Human Breast Cancer Specimens and Their Analysis Using Optical Projection Tomography
    10:10

    Long-term Culture of Human Breast Cancer Specimens and Their Analysis Using Optical Projection Tomography

    Published on: July 29, 2011

    Related Experiment Videos

    Last Updated: Jun 18, 2026

    Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
    15:48

    Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

    Published on: December 15, 2014

    Long-term Culture of Human Breast Cancer Specimens and Their Analysis Using Optical Projection Tomography
    10:10

    Long-term Culture of Human Breast Cancer Specimens and Their Analysis Using Optical Projection Tomography

    Published on: July 29, 2011

    Main Results:

    • Intertumoral heterogeneity was observed in MF/MC BC, with discordant CAB risk categories in 17% of patients.
    • A stepwise protocol revealed instances where clinical risk and CAB risk differed, highlighting prognostication complexity.
    • Analysis of 75 patients showed 11% with clinically high-risk tumors classified as CAB-low risk, and vice versa.

    Conclusions:

    • A tiered CAB testing approach is recommended for MF/MC BC.
    • Testing additional foci if the initial tumor shows CAB-low risk improves risk stratification.
    • This strategy aids personalized adjuvant treatment planning and minimizes undertreatment risk.