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Advancements in single-chain antibody functionalized nanoparticles for the treatment of advanced solid tumors

Tara Wieben1, Horacio Bach2

  • 1Department of Medicine, Faculty of Medicine, University of British Columbia, Kelowna, BC, Canada.

Nanomedicine (London, England)
|June 17, 2026
PubMed

Insights

Single-chain variable fragment (scFv) antibodies on nanoparticles show promise for solid tumor treatment by improving targeting and reducing resistance. This approach may overcome limitations of conventional chemotherapy and immunotherapy.

Area of Science:

  • Nanotechnology in oncology
  • Immunotherapy for solid tumors
  • Drug delivery systems

Background:

  • Conventional cancer therapies face challenges like low specificity and multidrug resistance.
  • Immunotherapy, while promising, is hindered by resistance and immunogenic reactions.
  • Nanoparticle-based drug delivery offers potential solutions for solid tumor treatment.

Purpose of the Study:

  • To review the design, limitations, and therapeutic applications of scFv-functionalized nanoparticles (NPs) for advanced solid tumors.
  • To explore how scFv-NPs can enhance tumor targeting, reduce immunogenicity, and improve drug delivery.
  • To identify future directions for scFv-NP development in cancer therapy.

Main Methods:

  • Systematic literature review of PubMed, Google Scholar, and ClinicalTrials.gov.
  • Inclusion of 62 articles published between 2010 and 2025.
  • Analysis of scFv-functionalized NPs in the context of solid tumor treatment.

Main Results:

  • scFv-functionalized NPs demonstrate potential to improve tumor targeting and drug delivery efficacy.
  • This approach may mitigate issues of therapeutic resistance and immunogenic reactions seen with other treatments.
  • The review highlights the versatility of scFv-NPs in addressing limitations of current cancer therapeutics.

Conclusions:

  • scFv-functionalized NPs represent a promising strategy for overcoming challenges in solid tumor therapy.
  • Future research should focus on engineering dual-sensitive nanocarriers and targeting cancer stem cells.
  • Biomarker-driven patient selection is crucial for successful clinical translation of these advanced therapies.
Keywords:
Cancer nanomedicineMM-302SGT-53TP-53scfvsolid tumors

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