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Updated: Jun 18, 2026

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

Published on: November 22, 2021

Psilocybin's kinematic effect on manual dexterity.

Pierre Klintefors¹, Chiranth Bhagavan², Richard Kanaan²

¹Philosophy & Cognitive Science, Lund University, Lund, Sweden. pierre.klintefors@lucs.lu.se.

Psychopharmacology

|June 17, 2026

Summary

Psilocybin, at low to moderate doses, did not significantly impair manual dexterity or hand coordination in healthy adults. This suggests psilocybin may be safely combined with motor rehabilitation therapies.

Keywords:

Box and block test Kinematic stability Manual dexterity Motor control Motor function PCA Psilocin Psilocybin

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Area of Science:

Neuroscience
Psychopharmacology
Rehabilitation Science

Background:

Growing clinical interest in psilocybin-assisted rehabilitation for motor disorders.
Limited research on psilocybin's specific motor effects, necessitating quantification for safety and efficacy assessment.

Purpose of the Study:

To determine if psilocybin acutely affects manual dexterity and coordination.
To evaluate psilocybin's impact on movement velocity, smoothness, and kinematic stability.

Main Methods:

Randomized, blinded trial administering psilocybin (5-20 mg) or placebo to healthy participants.
Manual dexterity assessed via Box and Block Test (BBT) at multiple time points.
Kinematic analysis of hand movements using 21 landmarks and principal component analysis (PCA).

Main Results:

A modest biphasic dose-response for BBT performance at higher doses (10-20 mg), with small effect sizes.
No significant changes in movement velocity or smoothness.
Stable coordination structure observed, with minor increases in finger movement complexity.

Conclusions:

Low to moderate psilocybin doses do not substantially impair manual dexterity or hand coordination.
Findings support the potential for integrating psilocybin with active motor rehabilitation programs.