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Related Concept Videos

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Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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Genome-wide Association Studies-GWAS

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Polygenic Traits01:18

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Polygenic Traits01:18

Polygenic Traits

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Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

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Updated: Jun 18, 2026

Establishing a Competing Risk Regression Nomogram Model for Survival Data
04:57

Establishing a Competing Risk Regression Nomogram Model for Survival Data

Published on: October 23, 2020

Polygenic Risk Scores for Breast Cancer Among African American Women With High Risk.

Yijia Sun1, Timothy Simmons2, James L Li1,3

  • 1Department of Public Health Sciences, University of Chicago, Chicago, Illinois.

JAMA Network Open
|June 17, 2026
PubMed
Summary
This summary is machine-generated.

Polygenic risk scores (PRSs) show promise for breast cancer (BC) risk stratification in African American women. A specific 162-variant PRS demonstrated high accuracy for triple-negative breast cancer (TNBC) risk assessment.

Related Experiment Videos

Last Updated: Jun 18, 2026

Establishing a Competing Risk Regression Nomogram Model for Survival Data
04:57

Establishing a Competing Risk Regression Nomogram Model for Survival Data

Published on: October 23, 2020

Area of Science:

  • Genetics
  • Oncology
  • Epidemiology

Background:

  • Validating polygenic risk scores (PRSs) is crucial for breast cancer (BC) risk stratification in high-risk populations.
  • African-ancestry PRSs require evaluation in diverse cohorts for clinical utility.

Purpose of the Study:

  • To assess the performance of African-ancestry PRSs for overall BC and triple-negative BC (TNBC) risk.
  • To evaluate PRSs in an independent cohort of African American women with a high familial risk of BC.

Main Methods:

  • A case-control study included 31,522 women of African ancestry undergoing genetic testing.
  • Six African-ancestry PRSs and one European-ancestry PRS were evaluated.
  • Performance was measured using area under the receiver operating characteristic curve (AUC) and odds ratios (OR).

Main Results:

  • African-ancestry PRSs showed improved performance over European-ancestry PRS for overall BC.
  • A 162-variant PRS demonstrated superior performance for TNBC, with an AUC of 0.609 and OR of 1.47.
  • PRSs performed well in women with a strong family history of BC.

Conclusions:

  • PRSs demonstrated good performance in African American women, particularly those with a strong family history of BC.
  • The 162-variant TNBC PRS shows potential as a cost-effective tool for risk assessment.
  • These findings support the use of PRSs to promote equitable breast cancer care.