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Related Concept Videos

Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Vaccinations01:51

Vaccinations

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Humoral Immune Responses01:36

Humoral Immune Responses

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Cross-reactivity00:42

Cross-reactivity

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Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Vaccine Production01:23

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...

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Updated: Jun 19, 2026

Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria
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Distinct Humoral Response Development to Measles Virus across Vaccine Platforms.

Andy K P Chan1,2, Jacqueline K Brockhurst1,3, Liting Liu1

  • 1W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

The Journal of Infectious Diseases
|June 17, 2026
PubMed
Summary

Different measles vaccine platforms induce unique antibody responses. VirScan technology revealed that wild-type measles virus infection provides broader epitope coverage than current vaccines, highlighting distinct immune profiles.

Keywords:
Antibody detectionChallenge studyHumoral immunityInfectionMeasles virusVaccination

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Published on: May 6, 2015

Area of Science:

  • Immunology
  • Vaccinology
  • Virology

Background:

  • Humoral immune responses to measles vaccines are not fully understood.
  • Different vaccine platforms may elicit varying antibody characteristics.

Purpose of the Study:

  • To compare antibody epitope coverage across various measles vaccine platforms.
  • To evaluate the effectiveness of VirScan technology in assessing anti-measles humoral immunity.

Main Methods:

  • VirScan, a phage-display immunoprecipitation sequencing technology, was used.
  • Antibody epitope reactivity was assessed after wild-type measles virus (MeV) infection, live-attenuated MeV vaccine (LAMV), MMR vaccine, or recombinant MeV hemagglutinin protein-based vaccine (rMeVH) in rhesus macaques.
  • Animals were challenged with WT MeV to assess recall responses.

Main Results:

  • Wild-type MeV infection induced broader epitope reactivity than LAMV-containing vaccines.
  • Recombinant MeV hemagglutinin protein-based vaccine (rMeVH) generated a narrow, distinct antibody profile.
  • All vaccine groups showed expanded antibody repertoires after WT MeV challenge.
  • MeV-specific VarScore correlated positively with IgG titer, avidity, and neutralizing titers.

Conclusions:

  • Vaccine platforms distinctly influence the breadth and specificity of anti-measles humoral responses.
  • VirScan is a valuable tool for comprehensive assessment of antibody epitope targets against measles virus.