Global brain maintenance predicts well-preserved cognitive function: A pooled analysis of three longitudinal...

Substantial heterogeneity in cognitive ageing is well documented. Such heterogeneity has been attributed to individual differences in brain maintenance - i.e., the relative preservation of neural resources in ageing. However, large-scale longitudinal evidence is currently lacking. In this study, we pooled data from three longitudinal population-based Swedish cohorts (total N = 1 356, 60-93 years at baseline, maximum follow-up duration: 7 years) to assess whether global brain maintenance is associated with better preserved cognition in ageing, and to identify lifestyle predictors of brain maintenance. In each cohort, global brain integrity was indexed by the volume of the lateral ventricles, and general cognitive function based on a principal component analysis of four age-sensitive cognitive domains. Participants were classified into subgroups of low (i.e., 'aged') versus high (i.e., 'youth-like') brain integrity based on comparison to ventricular volume estimates from a younger reference sample (N = 60, 25-55 years). Across cohorts, 881 individuals (64.97%) were classified into the high brain integrity subgroup at baseline and 409 individuals (49.82%) over the follow-up. Maintenance of more youth-like brain integrity was associated with better baseline cognition and less cognitive decline longitudinally. Moreover, lower cardiovascular disease risk and the absence of diabetes predicted brain maintenance at baseline and over the follow-up. These findings underscore general brain maintenance as a key determinant of cognitive ageing and highlight the importance of managing cardiovascular and metabolic disease risk factors for promotion of brain and cognitive health in later life.