Related Experiment Video
Updated: Jun 19, 2026

Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices
Published on: April 5, 2016
Two circuits, one stress: Dissecting the neural logic of comorbid fear and anhedonia
1School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China; MOE Frontier Science Center for Brain Science and Brain-Machine Integration, State Key Laboratory of Brain-Machine Intelligence, New Cornerstone Science Laboratory, Zhejiang University, Hangzhou 311121, China.
Abstract:
In this issue of Neuron, Li and colleagues1 unveil a circuit-based framework in which parallel insula-prefrontal circuits independently govern stress-induced social fear and novelty preference deficits, and lateral inhibition between these circuits via local parvalbumin interneurons drives their comorbidity.
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