Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Somatosensation01:33

Somatosensation

The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electroacupuncture Ameliorates Learning and Memory Deficits in Vascular Cognitive Impairment Rats Through Activation of the Supramammillary Nucleus-Dentate Gyrus Circuit.

CNS neuroscience & therapeutics·2026
Same author

Carbon nanotube fiber electrode-based implantable electroacupuncture ameliorates myocardial ischemia in rats via the FXR/SHP pathway.

Nanotechnology·2026
Same author

Recommendations for the DesIgn of sham acupuncture in RandomizEd Controlled Trials (the DIRECT guidelines).

Journal of integrative medicine·2026
Same author

Peripheral Electrical Nerve Stimulation Rescues Spatial Memory Deficits in Vascular Cognitive Impairment Rats by Engaging a Central Cholinergic Circuit.

Stroke·2026
Same author

Electroacupuncture Alleviates KOA-Induced Pain and Cartilage Degeneration via NGF/TrkA Pathway.

Journal of pain research·2026
Same author

Electroacupuncture at ST36 Alleviates Visceral Hypersensitivity by Suppressing Eosinophil-Induced TRPV1 Expression on Duodenum.

Pain research & management·2026
Same journal

High-dose furmonertinib as first-line treatment for untreated EGFR-mutated advanced NSCLC with central nervous system metastases: A phase 2 trial.

Cell reports. Medicine·2026
Same journal

Microglial IL-27 modulates depression-like behaviors induced by postnatal immune activation.

Cell reports. Medicine·2026
Same journal

Multi-omics profiling unveils biological and clinical insights into pulmonary sarcomatoid carcinoma.

Cell reports. Medicine·2026
Same journal

Case of complete response to immunotherapy in MMR-deficient prostate cancer associated with NK-like and CD4<sup>+</sup>CD8<sup>+</sup> T cells.

Cell reports. Medicine·2026
Same journal

Design optimization of antibody-ligand motifs to enhance CAR-T redirection activity against solid tumors.

Cell reports. Medicine·2026
Same journal

Advancing CAR-NK cell therapy in solid tumors: Current landscape and future directions.

Cell reports. Medicine·2026
See all related articles

Related Experiment Video

Updated: Jun 19, 2026

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

A predictive corticospinal model for pain perception.

Xiao-Min Lin1, Xiao-Shuo Zhang1, Hang Zhou2

  • 1State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China.

Cell Reports. Medicine
|June 17, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed a new corticospinal biomarker to accurately predict pain intensity. This novel tool, trained on fMRI data, shows promise for understanding and treating chronic pain conditions.

Keywords:
acupuncturechronic paincorticospinal fMRIneuromodulationpain biomarker

More Related Videos

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
07:09

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

Investigating Pain-Related Avoidance Behavior using a Robotic Arm-Reaching Paradigm
09:00

Investigating Pain-Related Avoidance Behavior using a Robotic Arm-Reaching Paradigm

Published on: October 3, 2020

Related Experiment Videos

Last Updated: Jun 19, 2026

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
07:09

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

Investigating Pain-Related Avoidance Behavior using a Robotic Arm-Reaching Paradigm
09:00

Investigating Pain-Related Avoidance Behavior using a Robotic Arm-Reaching Paradigm

Published on: October 3, 2020

Area of Science:

  • Neuroscience
  • Biomarkers
  • Pain Research

Background:

  • Pain perception involves complex corticospinal circuits.
  • Current neuroimaging biomarkers for pain are primarily brain-centric.
  • A need exists for biomarkers that capture the full corticospinal network's role in pain.

Purpose of the Study:

  • To develop and validate a novel corticospinal biomarker for pain intensity.
  • To assess the biomarker's accuracy, generalizability, and specificity compared to existing methods.
  • To investigate the biomarker's utility in tracking treatment-induced analgesia and chronic pain progression.

Main Methods:

  • Trained a multivariate model, the Corticospinal Pain Intensity Pattern, on 330 simultaneous corticospinal fMRI datasets.
  • Validated the model on independent datasets, including electrical pain stimuli.
  • Applied the model to healthy participants undergoing transcutaneous electrical nerve stimulation and a chronic pain cohort.
  • Utilized a corticospinal hidden Markov model to analyze dynamic neural state transitions.

Main Results:

  • The corticospinal model significantly outperformed cortical signatures in predicting pain intensity.
  • The model demonstrated generalizability to electrical pain and specificity against itch and observed pain.
  • The biomarker successfully tracked analgesia in healthy individuals and predicted baseline pain in chronic pain patients.
  • Dynamic state transitions identified by the hidden Markov model correlated with pain modulation.

Conclusions:

  • The Corticospinal Pain Intensity Pattern serves as a robust biomarker for pain intensity.
  • This corticospinal biomarker bridges experimental and clinical pain research by integrating evoked and spontaneous neural activity.
  • The findings support the development of novel, network-based approaches for pain assessment and treatment.