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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
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Related Experiment Video

Updated: Jun 19, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
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Precision-guided immunomodulatory therapy in sepsis

Jim M Smit1, Marcel J T Reinders2, Philip A van der Zee3

  • 1Data Science Group, Institute for Computing and Information Sciences, Radboud University, Nijmegen, Netherlands; Pattern Recognition & Bioinformatics Group, Delft University of Technology, Delft, Netherlands.

The Lancet. Respiratory Medicine
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No abstract available in PubMed .

Related Experiment Videos

Last Updated: Jun 19, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019