Regulating the Nano-Bio Interface: Converging Electrochemical and Photonic Biosensing for Wearable Diagnostics

Area of Science:

• Biomedical Engineering
• Materials Science
• Nanotechnology

Background:

• Wearable biosensors leverage nanomaterials, electronics, and miniaturized transduction for continuous monitoring.
• Electrochemical and photonic modalities offer complementary strengths in sensitivity, selectivity, and power efficiency for wearable applications.

Purpose of the Study:

• To review the integration of electrochemical and optical transduction in next-generation wearable diagnostic platforms.
• To examine the physical and functional demands of converging these modalities in wearable systems.

Main Methods:

• Highlighting model electrochemical systems like textile-integrated wound monitoring and hormone sensors.
• Discussing how optical modalities provide orthogonal observables for interfacial and biochemical conditions.
• Exploring emerging device architectures that combine electrochemical and optical interrogation.

Main Results:

• Convergence of electrochemical and optical methods offers enhanced capabilities for wearable diagnostics.
• Integrated platforms can generate robust, information-rich datasets for real-world applications.
• Textile-integrated sensors and hormone monitoring exemplify the potential of combined modalities.

Conclusions:

• The integration of electrochemical and optical sensing in wearable platforms is crucial for advancing personalized healthcare.
• These hybrid biosensors support long-term, real-world deployment for continuous monitoring applications.
• Future wearable diagnostics will benefit from robust, information-rich data generated by multimodal sensing.