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Updated: Jun 19, 2026

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Published on: May 2, 2025
[Comorbidity of premenstrual dysphoric disorder and bipolar disorder: Characteristics and interactions]
Mathilde Mongnet1, Julia Korngold2, Marc Masson3
1CMP Boissy-Saint-Léger, hôpital Albert-Chenevier (AP-HP), 94000 Créteil, France.
Objectives:
Premenstrual dysphoric disorder (PMDD), a severe form of premenstrual syndrome, is characterized by cyclic emotional and physical symptoms affecting quality of life. Bipolar disorder (BD), on the other hand, manifests itself through alternating manic, hypomanic and depressive episodes. This review aims to explore the comorbidity between PMDD and TB.
Methods:
A systematic review of the literature (PRISMA) was conducted from PubMed and Embase data up to June 2025.
Results:
Eighteen articles (13 original studies and five clinical cases) were included. PMDD and TB were frequently comorbid with notable consequences on the frequency and intensity of thymic episodes. The interactions appeared to be multifactorial and partly related to hormonal fluctuations, particularly variations in estrogen and progesterone. The effectiveness of pharmacological treatments and hormonal and psychotherapeutic approaches remain little studied. The analysis of the data highlighted the need for individualized care considering the cyclicality of symptoms.
Conclusions:
PMDD-BD comorbidity represents a clinically significant but still under-recognized condition with important prognostic implications. It seems essential to continue the exploration of this comorbidity by integrating both hormonal and mood-related dimensions, and to better diagnose and treat it so as to improve quality of life through personalized therapeutic strategies.
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