Related Experiment Video
Updated: Jun 19, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
Association between intrinsic capacity and dementia risk in older Mexicans
Miriam Teresa López-Teros1, Sara Gabriela Yeverino-Castro2, Fabiola Yocupicio-Medrano1
1Department of Nutrition, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Introduction:
Healthy aging reflects the maintenance of intrinsic capacity (IC) across five physical and mental domains. Although IC decline has been linked to frailty and mortality, evidence regarding its predictive value for dementia remains limited, particularly in low- and middle-income countries.
Methods:
Data from 7263 adults aged ≥60 years without baseline dementia from the Mexican Health and Aging Study (2012-2015) were analyzed. IC was assessed across vitality, locomotor, sensory, cognitive, and psychological domains. Dementia was defined as impairment in two or more cognitive domains plus one or more limitation in instrumental activities of daily living.
Results:
The mean age of the study population was 68.92 ± 6.8 years and 55.4% were women. Dementia incidence over 3 years was 4.15%. Higher baseline IC scores were associated with lower odds of incident dementia (adjusted odds ratio [OR] = 0.62; 95% confidence interval [CI]: 0.41-0.94).
Discussion:
Our findings support the role of IC as an early, multidimensional marker of cognitive vulnerability.
Related Concept Videos
Dementia l: Introduction
Alzheimer Disease l: Introduction
Dementia
The progression of dementia is generally gradual.
Alzheimer Disease ll: Pathophysiology
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Pharmacodynamics in Geriatric Patients: Effects of Age
