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Updated: Jun 19, 2026
Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
Published on: July 28, 2023
Modified Surgical Technique Combined with Radiation Therapy for Keloid Management
Xueqing Wang1,2, Kai Xie1,2, Yilei Wu1,2
1Department of Dermatologic Surgery, Dermatology Hospital of Shandong First Medical University, Jinan, 250000, Shandong, China.
Background:
Keloids are skin proliferative lesions with tumor-like characteristics. Their treatment is challenging due to their high recurrence rate. The most effective treatment against keloids is surgical excision with radiotherapy. However, the recurrence rate remains high.
Methods:
In this study, we modified the surgical technique by reducing the tension of an area three times larger than the residual wound area. We treated 89 patients using the modified surgical excision procedure with radiotherapy, and we assessed the appearance of the scar using the Vancouver scar scale (VSS) score.
Results:
The follow-up times ranged from 12 to 28 months with an average of 16.4 months. During the follow-up period, local recurrences were observed in 13 cases (14.6%). The mean VSS score decreased significantly after treatment (P < 0.001) indicating an improvement in the cosmetic appearance of scars.
Conclusion:
The modified surgical technique combined with radiation therapy may be an effective method for treating keloids.
Level Of Evidence Iv:
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
