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Related Experiment Videos

Theophylline protein binding in humans.

K J Simons, F E Simons, C J Briggs

    Journal of Pharmaceutical Sciences
    |February 1, 1979
    PubMed
    Summary
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    Theophylline protein binding in adults and asthmatic patients ranged from 58-82%, varying with age. Higher binding suggests considering protein-bound theophylline for optimal bronchodilation.

    Area of Science:

    • Pharmacology
    • Clinical Chemistry

    Background:

    • Theophylline is a common bronchodilator used in asthma management.
    • Understanding theophylline's protein binding is crucial for therapeutic drug monitoring.

    Purpose of the Study:

    • To determine the extent of theophylline protein binding in normal adults and pediatric asthmatic patients.
    • To investigate the correlation between theophylline protein binding and patient age.

    Main Methods:

    • Serum samples were collected from six normal adults and 42 asthmatic patients (aged 1-25 years).
    • Patients received a dose of 5 mg of theophylline/kg.
    • Theophylline protein binding was measured using established laboratory techniques.

    Main Results:

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  • Theophylline protein binding ranged from 58% to 82% across all participants.
  • The widest range of binding was observed in younger patients, though age did not correlate with the proportion of bound drug.
  • Observed binding levels were higher than previously reported in the literature.

    • Conclusions:

    • Theophylline protein binding is significant and can vary considerably, particularly in younger individuals.
    • Clinicians should consider the impact of protein binding on theophylline's efficacy.
    • Adjusting theophylline dosage or interpretation of serum concentrations may be necessary in patients with suboptimal bronchodilation despite therapeutic total serum levels (10-20 microgram/ml).