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CD45 as a multifunctional target in immune regulation and therapeutic delivery
Kaikai Zhao1, Ruohan Yang1, Mengli Li1
1School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
Background:
CD45, a receptor-type protein tyrosine phosphatase broadly expressed on leukocytes, is a critical regulator of signaling thresholds and immune cell activation. Dysregulation of CD45 has been implicated in a range of immune-related diseases and malignancies.
Main Body:
Recent advances have focused on modulating CD45 for disease treatment through various strategies, including regulating its expression level, structural conformation, and spatial membrane distribution. Beyond the immunomodulatory role, as a leukocyte-specific and broadly expressed biomarker, CD45 also has broad application in the field of drug delivery, such as the development of CD45 antibody-drug conjugates and a drug-loading site on live-cell carriers.
Conclusions:
This review systematically summarizes the immunoregulatory mechanisms of CD45 across various immune cell subsets and discusses CD45-based therapeutic interventions and drug delivery strategies, bridging basic immunology with therapeutic advancement.
Insights
CD45, a key regulator of immune cell activation, is explored for its dual role in immune regulation and targeted drug delivery. Modulating CD45 offers therapeutic potential for diseases and cancer.
Area of Science:
- Immunology
- Cell Biology
- Biochemistry
Background:
- CD45 is a leukocyte-specific protein tyrosine phosphatase crucial for immune cell signaling and activation.
- Aberrant CD45 function is linked to immune disorders and cancers.
Purpose of the Study:
- To review CD45's immunoregulatory mechanisms in different immune cells.
- To discuss CD45-based therapeutic strategies and drug delivery applications.
Main Methods:
- Systematic review of scientific literature.
- Analysis of CD45's role in immune cell signaling.
- Evaluation of therapeutic interventions targeting CD45.
- Assessment of CD45 as a biomarker for drug delivery.
Main Results:
- CD45 modulates signaling thresholds and immune cell activation across various subsets.
- Strategies to regulate CD45 expression, conformation, and distribution are being developed for therapy.
- CD45 serves as a biomarker for antibody-drug conjugates and live-cell drug carriers.
Conclusions:
- CD45 plays a multifaceted role in immunity and disease.
- Targeting CD45 presents promising therapeutic avenues.
- CD45's biomarker potential facilitates innovative drug delivery systems.
