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Related Experiment Videos

Turmeric-derived nanovesicles reprogram pathological NETosis to mitigate inflammatory bone loss.

Ming Wang1,2,3,4, Kamoran Tuerhong1, Ying Xie1

  • 1The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, 401147, China.

Journal of Nanobiotechnology
|June 18, 2026
PubMed

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Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Summary

Turmeric-derived nanovesicles (TNVs) effectively target and reduce neutrophil extracellular traps (NETs) and inflammation, offering a novel therapy for periodontitis and other inflammatory bone loss conditions.

Area of Science:

  • Biomaterials Science
  • Immunology
  • Nanotechnology

Background:

  • Inflammatory bone destruction, like in periodontitis, involves persistent inflammation and osteoclast activity, often amplified by neutrophil extracellular traps (NETs).
  • Current therapies targeting NETs have limitations in efficiency, bioavailability, and safety, necessitating advanced delivery systems.
  • Aberrant NET formation and dysregulated inflammatory microenvironments create a self-amplifying cycle of bone loss.

Purpose of the Study:

  • To develop a novel biomimetic nanodelivery system for targeting NET formation and associated inflammatory pathways.
  • To investigate the therapeutic potential of turmeric-derived nanovesicles (TNVs) in preclinical models of inflammatory bone loss.

Main Methods:

  • Single-cell transcriptomic analysis of existing datasets to identify NET formation as a therapeutic target in periodontitis.
Keywords:
ImmunomodulationInflammation-associated accumulationInflammatory bone destructionNeutrophil extracellular trapsPathological NETosisPlant-derived extracellular vesicles

Related Experiment Videos

  • Development of TNVs from turmeric, characterized by their plant-derived lipid bilayer and bioactive cargo.
  • In vitro and in vivo studies in a murine periodontitis model to evaluate TNV efficacy in suppressing NETosis, inflammation, and bone resorption.

    • Main Results:

    • TNVs demonstrated biocompatibility and efficient uptake by neutrophils, significantly suppressing NET formation by reducing ROS, CitH3, MPO, ELANE expression, and extracellular DNA release.
    • Transcriptomic analysis confirmed TNVs downregulate NET-associated pathways and enhance antioxidant/anti-inflammatory responses.
    • In vivo, TNVs accumulated at inflamed sites, inhibited NET formation and osteoclastogenesis, reduced inflammation, mitigated bone loss, and preserved bone microarchitecture.

    Conclusions:

    • TNVs represent a promising plant-derived biomimetic nanoplatform for targeted delivery to inflamed tissues.
    • TNVs exhibit potent immunomodulatory effects, offering a novel therapeutic strategy for inflammation-induced bone loss, including periodontitis.
    • The integrated bioactive cargo and efficient delivery capacity of TNVs provide a compelling approach to combatting inflammatory bone destruction.